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Titolo:
Clinicopathologic factors correlated with number of metastatic lymph nodesin oesophageal cancer
Autore:
Tachibana, M; Yoshimura, H; Kinugasa, S; Dhar, DK; Shibakita, M; Ohno, S; Ueda, S; Fujii, T; Nagasue, N;
Indirizzi:
Shimane Med Univ, Dept Surg 2, Izumo, Shimane 6938501, Japan Shimane Med Univ Izumo Shimane Japan 6938501 zumo, Shimane 6938501, Japan
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 7, volume: 33, anno: 2001,
pagine: 534 - 538
SICI:
1590-8658(200110)33:7<534:CFCWNO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; THORACIC ESOPHAGEAL CANCER; PROGNOSTIC-SIGNIFICANCE; SURVIVAL;
Keywords:
oesophageal lymph node metastases; oesophageal cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Tachibana, M Shimane Med Univ, Dept Surg 2, Enya Cho 89-1, Izumo, Shimane 6938501, Japan Shimane Med Univ Enya Cho 89-1 Izumo Shimane Japan 6938501 an
Citazione:
M. Tachibana et al., "Clinicopathologic factors correlated with number of metastatic lymph nodesin oesophageal cancer", DIG LIVER D, 33(7), 2001, pp. 534-538

Abstract

Background. The number of metastatic lymph nodes is applied to the stagingsystem of gastric cancer and colorectal cancer. However, it has not been evaluated in oesophageal cancer. Patients and Methods. Of 258 patients with primary squamous cell Carcinomaof the thoracic oesophagus between February 1981 and December 1999, 160 under-went three-field oesophagectomy with a curative intent. Clinicopathologic characteristics of those 160 patients were retrospectively investigated according to the number of metastatic lymph nodes. Results. Seventy-eight patients had no lymph node metastases and 82 (51.3%) had lymph node metastases; 51 (31.9%) had between 1 and 4 positive lymph nodes, and 31 (19.4%) had greater than or equal to5. The number of metastatic lymph nodes was significantly correlated with tumour size, macroscopic classification, histological differentiation, pT pN, and vessel invasions. Multivariate analysis showed that lymph vessel invasion (relative risk 12.6), histological differentiation (relative risk 4.2), and tumour size (relative risk 3.8) were independent factors correlated with number of metastatic lymph nodes. The number of metastatic lymph nodes was also well correlated with the Japanese nodal level and TNM stage, respectively (p<0.001). The 5-year disease-specific survival rate according to the number of positive lymph nodes was 90% for patients without lymph node metastases, 52.2% with 1-4, and 28.9% with <greater than or equal to>5, respectively, (p<0.0001; 0 vs1-4, p<0.05; 1-4 vs greater than or equal to5). Conclusion. The number of positive lymph nodes is well correlated with tumour progression and provides a useful prognostic indicator after oesophagectomy for oesophageal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 21:07:46