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Titolo:
Metastatic metaplastic carcinoma of the breast (MCB): An uncharacteristic pattern of presentation with clinicopathologic correlation
Autore:
Catroppo, JF; Lara, JF;
Indirizzi:
St Barnabas Hosp, Dept Pathol & Lab Med, Livingston, NJ 07039 USA St Barnabas Hosp Livingston NJ USA 07039 ab Med, Livingston, NJ 07039 USA
Titolo Testata:
DIAGNOSTIC CYTOPATHOLOGY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 285 - 291
SICI:
8755-1039(200111)25:5<285:MMCOTB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASPIRATION BIOPSY; DIAGNOSIS; CYTOLOGY; TUMORS;
Keywords:
breast neoplasms; metaplasia; metaplastic carcinoma; spindle cell; metastasis; lung; cytology; fine-needle aspiration biopsy (FNAB);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Lara, JF St Barnabas Hosp, Dept Pathol & Lab Med, 94 Old Short Hills Rd, Livingston, NJ 07039 USA St Barnabas Hosp 94 Old Short Hills Rd Livingston NJ USA 07039 SA
Citazione:
J.F. Catroppo e J.F. Lara, "Metastatic metaplastic carcinoma of the breast (MCB): An uncharacteristic pattern of presentation with clinicopathologic correlation", DIAGN CYTOP, 25(5), 2001, pp. 285-291

Abstract

Metaplastic carcinoma of the breast (MCB) is a well recognized but uncommon aberrant manifestation of poorly differentiated invasive carcinoma containing both epithelial (ductal) and mesenchymal elements as it-ell as a transitional form between them. This heterogeneous tumor characteristically contains ductal carcinoma cells mixed with areas of diverse morphologic phenotype displaying spindle, squamous, chondroid, or osseous differentiation. Some studies have suggested that certain types of metaplastic carcinoma ha ve a more favorable prognosis as compared with others. We describe a case involving a 67-yr-old woman who presented with metastatic nodules in the lungs and a vague but recent history of breast cancer. The Case highlights a subtype of MCB with a predominant spindle cell Component metastatic to the lung. Fine-needle aspiration biopsy (FNAB) smears of the nodules revealed a bland, spindle cell, mesenchymal proliferation with minimal evidence of an epithelial component. A second primary was clinically excluded and a request for review of the original slides identified a metaplastic component to the original tumor with a histologic and immunohistochemical profile identical to the metastatic, tumor, confirming origin from the breast. Metaplastic carcinomas of the breast commonly bypass axillary lymph nodes and present as distant metastases. FNAB diagnosis of metaplastic carcinoma of the breast is quite difficult tit the primary site and poses a formidable diagnostic challenge at a metastatic, site, especially when the dominant pattern is not of the usual type. The literature is reviewed, confirming the rarity of such a presentation and the novelty of this case. Confirmation by FNAB is alsoquite difficult but may become more commonplace as a trend toward minimal intervention continues to gain popularity. This case emphasizes the importance of recognizing and reporting metaplastic elements in primary breast tumors, as well as the value of direct morphologic comparison of cytologic material from FNABs with archival histologic material. In such situations, theimportance of Complete and accurate clinicopathologic information is underscored. Diagn. Cytopathol. 2001;25:285-291. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:44:13