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Titolo:
Overexpression of the A(1) adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance
Autore:
Dong, Q; Ginsberg, HN; Erlanger, BF;
Indirizzi:
Columbia Univ, Dept Microbiol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ept Microbiol, New York, NY 10032 USA Columbia Univ, Dept Human Nutr, New York, NY USA Columbia Univ New York NY USA ia Univ, Dept Human Nutr, New York, NY USA Columbia Univ, Dept Med, New York, NY USA Columbia Univ New York NY USAColumbia Univ, Dept Med, New York, NY USA
Titolo Testata:
DIABETES OBESITY & METABOLISM
fascicolo: 5, volume: 3, anno: 2001,
pagine: 360 - 366
SICI:
1462-8902(200110)3:5<360:OOTAAR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATED GLUCOSE-TRANSPORT; EXPRESSION; CELL; CATECHOLAMINES; PATHOGENESIS; CLONING; NIDDM; BRAIN;
Keywords:
A(1) adenosine receptor; obesity; insulin resistance; diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Erlanger, BF Columbia Univ, Dept Microbiol, 701 W 168th St, New York, NY 10032 USA Columbia Univ 701 W 168th St New York NY USA 10032 10032 USA
Citazione:
Q. Dong et al., "Overexpression of the A(1) adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance", DIABET OB M, 3(5), 2001, pp. 360-366

Abstract

In-vitro studies have implicated the A, adenosine receptor (A(1)AR) of adipocytes in inhibition of lipolysis, stimulation of lipogenesis and enhancement of the action of insulin on glucose metabolism. To determine whether any of these activities were physiologically relevant in an intact animal, A(1)AR was overexpressed in adipose tissue of transgenic mice. Lower plasma free fatty acid (FFA) levels were observed in the transgenic mice relative to the litter-matched controls. supporting a significant physiological role for adipocyte A(1)AR in the control of lipolysis. However, no differences were observed in body weights or body composition. On a high fat diet, both the transgenic mice and the litter matched controls, male and female, became equally obese. Unlike the control mice, however, the transgenic mice did not develop insulin resistance, as demonstrated by serum glucose and insulin levels and glucose and insulin tolerance tests. These findings demonstrate that adipocyte A(1)AR plays an important physiological role in the control of insulin sensitivity in an intact animal and therefore should be considered to be a potential therapeutic target for the treatment of obesity-related insulin resistance and type 2 diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 13:30:11