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Titolo:
Effects of granulocyte-colony stimulating factor in the treatment of diabetic foot infection
Autore:
Yonem, A; Cakir, B; Guler, S; Azal, O; Corakci, A;
Indirizzi:
Gulhane Sch Med, Dept Endocrinol, Ankara, Turkey Gulhane Sch Med Ankara Turkey Sch Med, Dept Endocrinol, Ankara, Turkey Ankara Educ & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey Ankara Educ & Res Hosp Ankara Turkey Endocrinol & Metab, Ankara, Turkey
Titolo Testata:
DIABETES OBESITY & METABOLISM
fascicolo: 5, volume: 3, anno: 2001,
pagine: 332 - 337
SICI:
1462-8902(200110)3:5<332:EOGSFI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY BURST; PERIPHERAL-BLOOD; NEUTROPHILS; MELLITUS; GLUCOSE; CELLS; CSF;
Keywords:
granulocyte-colony stimulating factor; diabetes mellitus; diabetic foot infection; respiratory burst; phagocytosis; polymorphonuclear leucocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Guler, S Ulucanlar Caddesi, 68-5 Cebeci, TR-06590 Ankara, Turkey UlucanlarCaddesi 68-5 Cebeci Ankara Turkey TR-06590 ara, Turkey
Citazione:
A. Yonem et al., "Effects of granulocyte-colony stimulating factor in the treatment of diabetic foot infection", DIABET OB M, 3(5), 2001, pp. 332-337

Abstract

Aims: Foot infections and the subsequent amputation of a lower extremity are the most common cause of hospitalization among patients with diabetes mellitus. Although there are several reasons for susceptibility to infection in diabetic patients, white blood cell dysfunction is considered to be an important cause for this tendency. Granulocyte-colony stimulating factor (G-CSF) increases the release of neutrophils from the bone marrow and improvesneutrophil functions. Based on this knowledge, the aim of the present study was to investigate the effects of addition of G-CSF to the treatment of foot infections in diabetic patients. Methods: Thirty diabetic patients with foot infection were included in thestudy. Fifteen of the patients received standard treatment consisting of local wound care and antibiotics (standard goup), and the other 15 patients received G-CSF besides standard treatment (G-CSF group). The objectives of this study were to determine the time to resolution of infection, time to hospital discharge, need for surgical intervention, and the effects of G-CSFon phagocytosis and respiratory burst of neutrophils. Results: Treatment with G-CSF led to significantly higher neutrophil counts on the 5th and loth days, and at the end of treatment in the G-CSF treated group compared to the standard group. Respiratory burst of neutrophils increased significantly in both the G-CSF group (from 1.6 +/-0.3 to 2.3 +/-0.5. p=0.001) and the standard group (from 2.0 +/-0.4 to 2.3 +/-0.4, p=0.02) with treatment. But, while phagocytosis of neutrophils increased significantly in the G-CSF group (from 70.4 +/-2.0 to 74.5 +/-1.9, p=0.004), it did not change significantly in the standard group (from 68.1 +/-0.2 to 69.4 +/-1.9, p=0.3) with treatment. Duration of hospitalization (26.9 +/-2.0 vs. 28.3 days, p<0.05), duration of parenteral antibiotic administration (22.9<plus/minus>2.0 vs. 23.3 +/-1.9 days, p<0.05), time to resolution of infection(23.6<plus/minus>1.8 vs. 22.3 +/-1.7 days, p<0.05), and need for amputation (13.3% vs. 20%, p>0.05) were similar between the G-CSF and the standard groups. Conclusions: Although G-CSF improves neutrophil function as well as increasing the absolute numbers, this improvement is not associated with shortening of duration of antibiotic administration, duration of hospital stay or need for amputation in diabetic foot infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:42:52