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Titolo:
Oxidant mechanisms in neonatal hypoxia-ischemia
Autore:
Ferriero, DM;
Indirizzi:
Univ Calif San Francisco, Div Child Neurol, Dept Neurol, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Calif San Francisco, Div Child Neurol, Dept Pediat, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA
Titolo Testata:
DEVELOPMENTAL NEUROSCIENCE
fascicolo: 3, volume: 23, anno: 2001,
pagine: 198 - 202
SICI:
0378-5866(200105/06)23:3<198:OMINH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; CENTRAL-NERVOUS-SYSTEM; RAT-BRAIN; SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE; NMDA RECEPTORS; MOUSE-BRAIN; FACTOR-I; INJURY; DAMAGE;
Keywords:
brain development; glutathione; glutathione peroxidase; hydrogen peroxide; hypoxia; iron; ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ferriero, DM Univ Calif San Francisco, Div Child Neurol, Dept Neurol, 521 Parnassus Ave,C215, San Francisco, CA 94143 USA Univ Calif San Francisco 521 Parnassus Ave,C215 San Francisco CA USA 94143
Citazione:
D.M. Ferriero, "Oxidant mechanisms in neonatal hypoxia-ischemia", DEV NEUROSC, 23(3), 2001, pp. 198-202

Abstract

The neonatal brain appears to be selectively vulnerable to oxidative stress. Several potential mechanisms associated with altered reactive oxygen species metabolism would explain the increased susceptibility. They include increased accumulation of hydrogen peroxide with subsequent neurotoxicity. This enhanced neurotoxicity from H2O2 accumulation may be related to inadequate scavenging abilities of the immature nervous system, such as lower glutathione peroxidase activity. Contributing to the immaturity of the scavenging enzymes is the inability of the developing nervous system to maintain glutathione stores. The immature nervous system is rich in iron, and has more free iron than the mature nervous system. As H2O2 accumulates because of these improper defense mechanisms, it is exposed to this free iron. This exposure results in the generation of OH radical (Fenton reaction), a more potent free radical that can cause severe damage. The rapid conversion of H2O2 to OH in the setting of free iron sets up the immature nervous system for increased cytotoxicity. Understanding the molecular mechanisms of oxidative stress will lead to better therapies for neonatal hypoxia-ischemia. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:48:47