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Titolo:
Cerebral hypoxia-ischemia in immature rats: Involvement of mitochondrial permeability transition?
Autore:
Puka-Sundvall, M; Gilland, E; Hagberg, H;
Indirizzi:
Univ Gothenburg, Dept Physiol, S-40530 Gothenburg, Sweden Univ GothenburgGothenburg Sweden S-40530 ol, S-40530 Gothenburg, Sweden Univ Gothenburg, Dept Anat & Cell Biol, S-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden S-40530 ol, S-40530 Gothenburg, Sweden Univ Gothenburg, Dept Clin Neurosci, S-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden S-40530 ci, S-40530 Gothenburg, Sweden Univ Gothenburg, Dept Obstet & Gynecol, Perinatal Ctr, S-40530 Gothenburg,Sweden Univ Gothenburg Gothenburg Sweden S-40530 Ctr, S-40530 Gothenburg,Sweden
Titolo Testata:
DEVELOPMENTAL NEUROSCIENCE
fascicolo: 3, volume: 23, anno: 2001,
pagine: 192 - 197
SICI:
0378-5866(200105/06)23:3<192:CHIIRI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-BRAIN-BARRIER; CYCLOSPORINE-A PROTECTS; ENERGY-METABOLISM; GLUCOSE-UTILIZATION; REPERFUSION INJURY; HEART-MITOCHONDRIA; EARLY RECOVERY; FREE-RADICALS; CELL-DEATH; DAMAGE;
Keywords:
brain damage; hypoxia-ischemia; immature rats; mitochondria; neonatal rats; permeability transition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Puka-Sundvall, M Univ Gothenburg, Dept Physiol, Box 432, S-40530 Gothenburg, Sweden Univ Gothenburg Box 432 Gothenburg Sweden S-40530 Sweden
Citazione:
M. Puka-Sundvall et al., "Cerebral hypoxia-ischemia in immature rats: Involvement of mitochondrial permeability transition?", DEV NEUROSC, 23(3), 2001, pp. 192-197

Abstract

(T)he aim of this study was to evaluate the involvement of mitochondrial membrane permeability transition (MPT) after hypoxia-ischemia (HI) in 7-day-old rats. [C-14]2-deoxyglucose (DOG) was administered to controls, and at various time points after Hl. MPT in the cerebral cortex was measured as entrapment of DOG-6-P in mitochondria. Another group of rats was treated with the MPT inhibitor cyclosporin A (CsA; 10-50 mg/kg i.p.) or vehicle before and after HI, and the effect on brain injury and mitochondrial respiration was evaluated. A significant increase in DOG-6-P entrapment in mitochondria indicated that MPT occurred in two phases: a primary MPT after 0-1.5 h and a secondary MPT after 6.5-8 h of reperfusion. However, CsA did not affect brain injury or mitochondrial respiration. The data suggest that MPT occurred after HI but does not provide evidence for its involvement in the development of injury. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 06/04/20 alle ore 01:55:09