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Titolo:
Delayed cerebral atrophy following moderate hypoxia-ischemia in the immature rat
Autore:
Geddes, R; Vannucci, RC; Vannucci, SJ;
Indirizzi:
Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Pediat, Hershey,PA 17033 USA Penn State Univ Hershey PA USA 17033 d, Dept Pediat, Hershey,PA 17033 USA Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Anat & Neurosci,Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 nat & Neurosci,Hershey, PA 17033 USA
Titolo Testata:
DEVELOPMENTAL NEUROSCIENCE
fascicolo: 3, volume: 23, anno: 2001,
pagine: 180 - 185
SICI:
0378-5866(200105/06)23:3<180:DCAFMH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-DAMAGE; PERINATAL BRAIN; APOPTOSIS;
Keywords:
ischemia; perinatal hypoxia-ischemia; hypoxia; apoptosis; cerebral atrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Vannucci, SJ Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Pediat, H-085,POB 850, Hershey, PA 17033 USA Penn State Univ H-085,POB 850 Hershey PA USA 17033 17033 USA
Citazione:
R. Geddes et al., "Delayed cerebral atrophy following moderate hypoxia-ischemia in the immature rat", DEV NEUROSC, 23(3), 2001, pp. 180-185

Abstract

Hypoxia-ischemia (H/I) damages cells in the immature brain and interferes with subsequent brain development; the extent of the damage has been related to the severity, or duration, of the initial insult. This study examined the effects of both severe and moderate duration of H/I on the evolution ofdamage through 8 weeks of recovery. Seven-day-old rat pups were subjected to either 75 min or 2 h of 8% oxygen following a unilateral carotid artery ligation. Evaluation of brain damage included morphometric analysis of hemispheric diameter at 2, 4, and 8 weeks of recovery, and hematoxylin and eosin for evaluation of pathology at 8 weeks. Two hours of H/I produced severe infarction in the ipsilateral hemisphere in the majority of the survivors, apparent by 2 weeks of recovery with no change at 4 or 8 weeks. In marked contrast, 75 min of H/I produced no significant damage during the initial 2 weeks of recovery but resulted in progressive cerebral atrophy with delayedinfarction such that the lextent of damage at 8 weeks was not different from the 2-hour group. Thus, even a mild-moderate ischemic insult to the perinatal brain establishes a vulnerable region which ultimately dies without intervention. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:32:22