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Titolo:
UNC-119 suppresses axon branching in C-elegans
Autore:
Knobel, KM; Davis, WS; Jorgensen, EM; Bastiani, MJ;
Indirizzi:
Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 Biol, Salt Lake City, UT 84112 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 20, volume: 128, anno: 2001,
pagine: 4079 - 4092
SICI:
0950-1991(200110)128:20<4079:USABIC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE-GATED CHANNEL; GROWTH CONE GUIDANCE; CAENORHABDITIS-ELEGANS; NEUROMUSCULAR-JUNCTION; PHOTORECEPTOR PROTEIN; SYMPATHETIC NEURONS; TARGET RECOGNITION; NERVE; EXPRESSION; MECHANISMS;
Keywords:
growth cone; axon branching; sprouting; neuron stabilization; unc-119; Caenorhabditis elegans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Jorgensen, EM Univ Utah, Dept Biol, 257 South 1400 East, Salt Lake City, UT 84112 USA Univ Utah 257 South 1400 East Salt Lake City UT USA 84112 SA
Citazione:
K.M. Knobel et al., "UNC-119 suppresses axon branching in C-elegans", DEVELOPMENT, 128(20), 2001, pp. 4079-4092

Abstract

The architecture of the differentiated nervous system is stable but the molecular mechanisms that are required for stabilization are unknown. We characterized the gene unc-119 in the nematode Caenorhabditis elegans and demonstrate that it is required to stabilize the differentiated structure of thenervous system. In unc-119 mutants, motor neuron commissures are excessively branched in adults. However, live imaging demonstrated that growth cone behavior during extension was fairly normal with the exception that the overall rate of migration was reduced. Later, after development was complete, secondary growth cones sprouted from existing motor neuron axons and cell bodies. These new growth cones extended supernumerary branches to the dorsalnerve cord at the same time the previously formed axons retracted. These defects could be suppressed by expressing the UNC-119 protein after embryonic development; thus demonstrating that UNC-119 is required for the maintenance of the nervous system architecture. Finally, UNC-119 is located in neuron cell bodies and axons and acts cell-autonomously to inhibit axon branching.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:17:03