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Titolo:
The Swedish APP670/671 Alzheimer's disease mutation: The first evidence for strikingly increased oxidative injury in the temporal inferior cortex
Autore:
Bogdanovic, N; Zilmer, M; Zilmer, K; Rehema, A; Karelson, E;
Indirizzi:
Univ Tartu, Dept Biochem, Fac Med, EST-50411 Tartu, Estonia Univ Tartu Tartu Estonia EST-50411 em, Fac Med, EST-50411 Tartu, Estonia Karolinska Inst, Dept Geriatr, Neurotec, Stockholm, Sweden Karolinska Inst Stockholm Sweden t Geriatr, Neurotec, Stockholm, Sweden
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 6, volume: 12, anno: 2001,
pagine: 364 - 370
SICI:
1420-8008(200111/12)12:6<364:TSAADM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; GLUTAMINE-SYNTHETASE; DOWNS-SYNDROME; STRESS; EXPRESSION; PLAQUES; BRAIN;
Keywords:
Swedish APP mutation; oxidative stress; temporal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Karelson, E Univ Tartu, Dept Biochem, Fac Med, Ravila St 19, EST-50411 Tartu, Estonia Univ Tartu Ravila St 19 Tartu Estonia EST-50411 artu, Estonia
Citazione:
N. Bogdanovic et al., "The Swedish APP670/671 Alzheimer's disease mutation: The first evidence for strikingly increased oxidative injury in the temporal inferior cortex", DEMENT G C, 12(6), 2001, pp. 364-370

Abstract

To evaluate the level of oxidative stress (OS) in familial Alzheimer's disease (FAD), we analysed four cerebrocortical areas from patients with Swedish FAD bearing the APP670/671 mutation. The temporal inferior cortex (TIC) from Swedish FAD patients revealed a striking 2- to 3-fold increase in diene conjugates, lipid peroxides and protein carbonyls, compared to sporadic Alzheimer's disease (AD). Compared with TIC from sporadic AD patients, the mutation carriers showed a markedly decreased activity of catalase (CAT) in the same area, and the same trend was found for another antioxidant enzyme,superoxide dismutase. These results are consistent with the deep oxidativeinjury of TIC in Swedish FAD. In the frontal inferior cortex (FIC), sensory postcentral cortex (SPCC) and occipital primary cortex (OPC) from SwedishFAD, the parameters of oxidative injury tended to be higher than in sporadic AD. Only the increase in the levels of lipid hydroperoxides in SPCC and of protein carbonyls in OPC was significant. Compared to sporadic AD, Swedish FAD showed a significant increase in GSSG levels and the GSSG/2GSH ratioin the FIC, SPCC and OPC. A significantly decreased activity of CAT was detectable for the SPCC and OPC in Swedish FAD. Increased CIS might play a crucial role in the rapid progression of Swedish FAD from the associative temporal cortex to the primary cerebrocortical areas. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:03:23