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Titolo:
Cigarette smoking and hypertension influence nitric oxide release and plasma levels of adhesion molecules
Autore:
Mazzone, A; Cusa, C; Mazzucchelli, I; Vezzoli, M; Ottini, E; Ghio, S; Tossini, G; Pacifici, R; Zuccaro, P;
Indirizzi:
Ist Super Sanita, Dept Clin Biochem, I-00161 Rome, Italy Ist Super SanitaRome Italy I-00161 pt Clin Biochem, I-00161 Rome, Italy Legnano Gen Hosp, Milan, Italy Legnano Gen Hosp Milan ItalyLegnano Gen Hosp, Milan, Italy Univ Pavia, Dept Cardiol, IRCCS, S Matteo Hosp, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 RCCS, S Matteo Hosp, I-27100 Pavia, Italy IRCCS, Ist Nazl Malattie Infett, Rome, Italy IRCCS Rome ItalyIRCCS, Ist Nazl Malattie Infett, Rome, Italy
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 9, volume: 39, anno: 2001,
pagine: 822 - 826
SICI:
1434-6621(200109)39:9<822:CSAHIN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT DILATION; UNSTABLE ANGINA; E-SELECTIN; INCREASED EXPRESSION; MONOCYTE ADHESION; ELEVATED LEVELS; ARTERY DISEASE; UP-REGULATION; ATHEROSCLEROSIS; SYNTHASE;
Keywords:
hypertension; smoking; cotinine; soluble adhesion molecules; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Zuccaro, P Ist Super Sanita, Dept Clin Biochem, Viale Regina Elena 299M, I-00161 Rome, Italy Ist Super Sanita Viale Regina Elena 299M Rome Italy I-00161 ly
Citazione:
A. Mazzone et al., "Cigarette smoking and hypertension influence nitric oxide release and plasma levels of adhesion molecules", CLIN CH L M, 39(9), 2001, pp. 822-826

Abstract

Progression of atherosclerosis is currently believed to involve interactions between leukocytes and vascular endothelium. Epidemiological risk factors for atherosclerosis such as hypertension and smoking are known to cause endothelial dysfunction, which is an early event in the atherosclerotic process; they also may be considered in the light of their effects on adhesion molecule expression and release. Little is known about the additive effect between these two risk factors on endothelial adhesion molecule expression and nitric oxide release. Soluble adhesion molecules and the nitric oxide were quantified in smoking hypertensive patients in comparison to those frompatients with hypertension alone. Cotinine, a stable metabolite of nicotine, has been used to identify smokers. One hundred and three hypertensive patients were selected: 51 smokers (plasma cotinine levels > 25 ng/ml) and 52non-smokers. Plasma concentrations of soluble intercellular cell adhesion molecule-1 (sICAM-1), soluble endothelial leukocyte adhesion molecule-1 (sELAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were quantified with ELISA methods. Plasma concentration of nitric oxide metabolites was measured by HPLC, whilst plasma concentration of cotinine was measured byRIA. Significant increases of sICAM-1 and sVCAM-1 were demonstrated in smokers (p < 0.001 and p < 0.05, respectively). In the same patients, a positive significant correlation between sVCAM-1 and plasma cotinine levels was observed (p < 0.002). Nitric oxide metabolites were reduced significantly (p < 0.04) in smokers. In conclusion, our data show that the two risk factors, smoking and hypertension, are additive risk factors in generating endothelial dysfunction andvascular damage, which plays a key role in atherogenesis.

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Documento generato il 26/01/20 alle ore 09:56:59