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Titolo:
Reversible autonomic dysfunction in hyperthyroid patients affects gastric myoelectrical activity and emptying
Autore:
Barczynski, M; Thor, P;
Indirizzi:
Jagiellonian Univ, Coll Med, Chair Gen Surg 3, Dept Endocrine Surg, PL-31202 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31202 e Surg, PL-31202 Krakow, Poland Jagiellonian Univ, Coll Med, Dept Expt Pathophysiol, PL-31202 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31202 hysiol, PL-31202 Krakow, Poland
Titolo Testata:
CLINICAL AUTONOMIC RESEARCH
fascicolo: 4, volume: 11, anno: 2001,
pagine: 243 - 249
SICI:
0959-9851(200108)11:4<243:RADIHP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; THYROID-HORMONE; BLOOD-PRESSURE; RELIABILITY; MOTILITY; SYSTEM;
Keywords:
heart rate variability; hyperthyroidism; autonomic dysfunction; gastric emptying; electrogastrography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Barczynski, M Jagiellonian Univ, Coll Med, Chair Gen Surg 3, Dept Endocrine Surg, Pradnicka 35-37, PL-31202 Krakow, Poland Jagiellonian Univ Pradnicka 35-37 Krakow Poland PL-31202 nd
Citazione:
M. Barczynski e P. Thor, "Reversible autonomic dysfunction in hyperthyroid patients affects gastric myoelectrical activity and emptying", CLIN AUTON, 11(4), 2001, pp. 243-249

Abstract

The autonomic nervous system (ANS) function in hyperthyroidism has been sofar investigated mainly from the cardiovascular point of view. The aim of this study is to show that the ANS dysfunction in hyperthyroidism is also expressed in gastric myoelectrical activity disturbances and gastric emptying disorders and to search for a correlation between the severity of clinical manifestation and free thyroid hormone levels and the degree of the ANS dysfunction. The analyzed group included 50 recently diagnosed patients withhyperthyroidism who were examined twice: before and after 3 months of thyrostatic treatment. Results were compared with those of a sex-, age- and BMI-matched control group of 50 healthy volunteers. The study included: heart rate variability analysis in time and frequency domain, at rest and during a deep-breathing test, surface electrogastrography in preprandial and postprandial periods measured simultaneously with the ultrasound assessment of gastric emptying time by Bolondi method. In patients with hyperthyroidism incomparison with the control group, the following significant differences were observed: a sharp reduction of the high-frequency component and a decrease of heart rate variability, a high incidence of dysrhythmia with dominant bradyarrhythmia, and a delay of gastric emptying. The degree of disordersrelated to the degree of clinical manifestation of hyperthyroidism's symptoms and free triiodothyronine serum concentration both. All the disorders were functional and disappeared in a stable euthyroidism. To conclude, the ANS dysfunction in hyperthyroidism results not only in withdrawal of vagal inhibitory effect on sinoatrial node, but in impaired mutual neuro-hormonal regulation (decrease of vagal influence) of gastric myoelectrical activity followed by delay of gastric emptying.

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Documento generato il 08/04/20 alle ore 23:54:14