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Titolo:
Post-stroke depression, antidepressant treatment and rehabilitation results - A case-control study
Autore:
Paolucci, S; Antonucci, G; Grasso, MG; Morelli, D; Troisi, E; Coiro, P; De Angelis, D; Rizzi, F; Bragoni, M;
Indirizzi:
Fdn Santa Lucia, IRCCS, I-00179 Rome, Italy Fdn Santa Lucia Rome Italy I-00179 nta Lucia, IRCCS, I-00179 Rome, Italy Univ Roma La Sapienza, Dept Psychol, Rome, Italy Univ Roma La Sapienza Rome Italy La Sapienza, Dept Psychol, Rome, Italy
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 3, volume: 12, anno: 2001,
pagine: 264 - 271
SICI:
1015-9770(2001)12:3<264:PDATAR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND TRIAL; POSTSTROKE DEPRESSION; FUNCTIONAL RECOVERY; SUNNYBROOK STROKE; FOLLOW-UP; DISABILITY; FLUOXETINE; THERAPY; DRUGS; IMPAIRMENT;
Keywords:
cerebrovascular disorders; depression; rehabilitation; antidepressive agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Paolucci, S Fdn Santa Lucia, IRCCS, Via Ardeatina 306, I-00179 Rome, ItalyFdn Santa Lucia Via Ardeatina 306 Rome Italy I-00179 e, Italy
Citazione:
S. Paolucci et al., "Post-stroke depression, antidepressant treatment and rehabilitation results - A case-control study", CEREB DIS, 12(3), 2001, pp. 264-271

Abstract

The aim of this study was to assess the specific influence of poststroke depression (PSD) on both basal functional status and rehabilitation results. We performed a case-control study in 290 stroke inpatients, matched for age (+/-1 year) and onset admission interval (+/-3 days) and divided in two groups according to the presence (PSD+) or absence (PSD-) of PSD. All PSD+ patients were treated with antidepressants (AD), mainly with fluoxetine. PSD patients, despite similar severity of stroke, showed greater disability in coping with activities of daily living (ADL) on admission and greater disability both in ADL and mobility at discharge than PSD- patients. Although both groups exhibited similar average functional improvement during rehabilitation, PSD- patients were nearly twice as likely to show excellent recovery both on ADL and mobility as PSD+ patients (OR = 1.95, 95% CI = 1.01-3.75and OR = 2.23, 95% Cl = 1.14-4.35, respectively). All AD drugs improved depressive symptoms. Few relevant side effects were observed: fluoxetine was discontinued in 2 patients because of insomnia and in 2 patients because ofnausea; paroxetine was stopped in 1 patient because of nausea and dry mouth. Our results confirm the unfavorable influence of PSD on functional outcome, despite pharmacological treatment. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 18/01/20 alle ore 21:52:53