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Titolo:
Nerve growth factor and transforming growth factor-beta serum levels in acute stroke patients - Possible involvement of neurotrophins in cerebrovascular disease
Autore:
Stanzani, L; Zoia, C; Sala, G; Appollonio, I; Frattola, L; De Simoni, MG; Ferrarese, C;
Indirizzi:
Univ Milano Bicocca, Osped S Gerardo, Dept Neurol, I-20052 Monza, Italy Univ Milano Bicocca Monza Italy I-20052 ept Neurol, I-20052 Monza, Italy Mario Negri Inst Pharmacol Res, Dept Neurosci, Milan, Italy Mario Negri Inst Pharmacol Res Milan Italy Dept Neurosci, Milan, Italy
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 3, volume: 12, anno: 2001,
pagine: 240 - 244
SICI:
1015-9770(2001)12:3<240:NGFATG>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; PC12 CELLS; HIPPOCAMPAL-NEURONS; EXPRESSION; GROWTH-FACTOR-BETA-1; DEATH; BRAIN; SECRETION; RECEPTORS; TRANSIENT;
Keywords:
stroke; serum; neurotrophins; nerve growth factor; transforming growth factor-beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ferrarese, C Univ Milano Bicocca, Osped S Gerardo, Dept Neurol, Via Donizetti 106, I-20052 Monza, Italy Univ Milano Bicocca Via Donizetti 106 Monza Italy I-20052 ly
Citazione:
L. Stanzani et al., "Nerve growth factor and transforming growth factor-beta serum levels in acute stroke patients - Possible involvement of neurotrophins in cerebrovascular disease", CEREB DIS, 12(3), 2001, pp. 240-244

Abstract

Background and Purpose: Experimental evidence indicates cytokine and neurotrophin production in brain tissue after stroke. Since neurotrophins may also be released from blood cells, we measured nerve growth factor (NGF) and transforming growth factor (TGF)-beta serum levels in 40 patients at various times after stroke and compared them to those in 20 healthy controls. Methods: Venous blood was obtained 1, 4, 10, 30 and 90 days after stroke and NGF and TGF-beta serum levels were measured by commercial ELISA. Values at each time were correlated with stroke severity, assessed using the National Institute of Health Stroke Scale, and with lesion volume, calculated using Cavalieri's direct estimator on a computerized tomography scan performed 5 days after stroke. Results and Conclusions: Although no significant differences between the two groups were demonstrated, in stroke patients, serum neurotrophins were significantly associated with clinical and neuroradiological parameters of brain injury and positively correlated with each other in the acute phases of stroke, suggesting that stroke may modulate peripheral neurotrophin levels. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 30/10/20 alle ore 00:46:33