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Titolo:
Outcome in patients with symptomatic occlusion of the internal carotid artery or intracranial arterial lesions: A meta-analysis of the role of baseline characteristics and type of antithrombotic treatment
Autore:
Klijn, CJM; Kappelle, LJ; Algra, A; van Gijn, J;
Indirizzi:
Univ Med Ctr Utrecht, Dept Neurol, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Julius Ctr Gen Practice & Patient Oriented Res, Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands nted Res, Utrecht, Netherlands Rudolf Magnus Inst Neurosci, NL-3508 TA Utrecht, Netherlands Rudolf MagnusInst Neurosci Utrecht Netherlands NL-3508 TA , Netherlands
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 3, volume: 12, anno: 2001,
pagine: 228 - 234
SICI:
1015-9770(2001)12:3<228:OIPWSO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDDLE CEREBRAL-ARTERY; TRANSIENT ISCHEMIC ATTACKS; NATURAL-HISTORY; HEMODYNAMIC FACTORS; PROGNOSIS; STENOSIS; DISEASE; REACTIVITY; BYPASS; STROKE;
Keywords:
outcome; occlusion; carotid artery; middle cerebral artery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Klijn, CJM Univ Med Ctr Utrecht, Dept Neurol, C03-236,POB 85500, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht C03-236,POB 85500 Utrecht Netherlands NL-3508 GA
Citazione:
C.J.M. Klijn et al., "Outcome in patients with symptomatic occlusion of the internal carotid artery or intracranial arterial lesions: A meta-analysis of the role of baseline characteristics and type of antithrombotic treatment", CEREB DIS, 12(3), 2001, pp. 228-234

Abstract

Objectives: We performed a systematic review of the literature to assess the impact of potential risk factors of recurrent stroke other than a compromised cerebral blood flow in patients with carotid occlusion or intracranial arterial lesions. In addition, we investigated the effect of treatment with aspirin or oral anticoagulation on recurrent stroke rate and assessed whether the incidence of recurrent stroke has decreased over the years. Methods:We searched Medline (1966 and onwards) and reference lists of identifiedarticles for papers reporting on the recurrent stroke risk in patients with carotid occlusion or intracranial arterial lesions. Two authors independently extracted information from all papers. The influence of study characteristics on the risk of the endpoints 'recurrent stroke', 'ipsilateral stroke' and 'vascular death' was determined by Poisson regression analysis. Rateratios were calculated per 10 percentage points increase of a characteristic. Results and Conclusions: Patients with intracranial carotid stenosis orocclusion had a higher rate of recurrent stroke (rate ratio 1.09; 95% Cl 1.05-1.14) than patients with extracranial carotid occlusion or middle cerebral artery stenosis or occlusion. In patients with bilateral carotid occlusion the rate was lower (rate ratio 0.82; 95% Cl 0.68-0.98). No other vascular risk factors than hypertension (rate ratio 1.23; 95% CI 1.07-1.41) couldbe shown to increase the rate of recurrent stroke. Oral anticoagulation but not aspirin had a protective effect on the incidence of recurrent stroke (rate ratio 0.86; 95% CI 0.79-0.93). The reported rates of recurrent strokein patients with symptomatic occlusion of the internal carotid artery or intracranial arterial lesions have not decreased over the years. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 07/08/20 alle ore 00:27:34