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Titolo:
Correlation between diffusion- and perfusion-weighted MRI and neurologicaldeficit measured by the Scandinavian Stroke Scale and Barthel Index in hyperacute subcortical stroke (<= 6 hours)
Autore:
Rohl, L; Geday, J; Ostergaard, L; Simonsen, CZ; Vestergaard-Poulsen, P; Andersen, G; Le Bihan, D; Gyldensted, C;
Indirizzi:
Aarhus Univ Hosp, Dept Neuroradiol, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Aarhus Denmark C Neuroradiol, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp, Dept Neurol, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 Neurol, DK-8000 Aarhus, Denmark CEA, Serv Hosp Frederic Joliot, F-91406 Orsay, France CEA Orsay France F-91406 erv Hosp Frederic Joliot, F-91406 Orsay, France
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 3, volume: 12, anno: 2001,
pagine: 203 - 213
SICI:
1015-9770(2001)12:3<203:CBDAPM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE ISCHEMIC STROKE; CEREBRAL BLOOD-FLOW; HIGH-RESOLUTION MEASUREMENT; TRACER BOLUS PASSAGES; LESION VOLUMES; TISSUE; INJURY; EVOLUTION; THERAPIES; PREDICTS;
Keywords:
diffusion-weighted imaging; magnetic resonance imaging; perfusion-weighted imaging; penumbra; stroke, acute;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Rohl, L Aarhus Univ Hosp, Dept Neuroradiol, Norrebrogade 44, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Norrebrogade 44 Aarhus Denmark C rhus C, Denmark
Citazione:
L. Rohl et al., "Correlation between diffusion- and perfusion-weighted MRI and neurologicaldeficit measured by the Scandinavian Stroke Scale and Barthel Index in hyperacute subcortical stroke (<= 6 hours)", CEREB DIS, 12(3), 2001, pp. 203-213

Abstract

Objective: We used combined diffusion-weighted (DWI) and perfusion-weighted (PWI) MRI to characterize hyperacute infarctions within 6 h of symptom onset with special reference to subcortical infarctions, and investigated therelation between perfusion-diffusion mismatch volume and functional outcome. Material and Methods: Twenty-two patients presenting with symptoms of acute stroke underwent DWI and PWI within 6 h of symptom onset, and follow-upMRI 30 days later. Twelve of these had a subcortical infarction on acute DWI. Lesion volumes were measured by acute DWI and PWI as well as chronic T-2-weighted MRI (T2WI). Clinical severity was measured by the Scandinavian Stroke Scale (SSS) and the Barthel Index (bI). Results: In the 12 patients with subcortical infarctions, PWI and especially DWI correlated strongly with acute and chronic neurological SSS score, as well as with final infarct volume. Furthermore, a hyperacute PWI/DWI mismatch in this subgroup predicted lesion growth. There was a weaker correlation between acute DWI/PWI and neurological score among all 22 patients, and patients with a PWI/DWI mismatch larger than 100 ml had a significantly larger lesion growth and a pooreroutcome than patients with a smaller mismatch. Conclusions: Subcortical infarctions may represent a sizeable subgroup of acute stroke patients. Also subcortical infarctions may have a PWI/DWI mismatch and therefore may respond to neuroprotective/ thrombolytic therapy. Hyperacute DWI may reflect theacute clinical status and predict the outcome in patients with subcorticalinfarction. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 20/01/20 alle ore 07:21:56