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Titolo:
Effect of 7 beta-hydroxycholesterol on cellular redox status and heat shock protein 70 expression in macrophages
Autore:
Bansal, G; Singh, U; Bansal, MP;
Indirizzi:
Punjabi Univ, Dept Biophys, Chandigarh 160014, India Punjabi Univ Chandigarh India 160014 t Biophys, Chandigarh 160014, India
Titolo Testata:
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
fascicolo: 5, volume: 11, anno: 2001,
pagine: 241 - 246
SICI:
1015-8987(2001)11:5<241:EO7BOC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ENDOTHELIAL-CELLS; GLUTATHIONE DEPLETION; OXIDIZED-LDL; CHOLESTEROL OXIDATION; GENE-EXPRESSION; ATHEROSCLEROSIS; STRESS; LOCALIZATION; OXYSTEROLS; INHIBITION;
Keywords:
glutathione; heat shock proteins; hsp70; 7 beta-hydroxycholesterol; macrophages; oxysterols; redox status;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Bansal, MP Punjabi Univ, Dept Biophys, Chandigarh 160014, India Punjabi Univ Chandigarh India 160014 Chandigarh 160014, India
Citazione:
G. Bansal et al., "Effect of 7 beta-hydroxycholesterol on cellular redox status and heat shock protein 70 expression in macrophages", CELL PHYS B, 11(5), 2001, pp. 241-246

Abstract

The proatherogenic effects of oxidized low-density lipoproteins are attributed to oxysterols, particularly 7 beta -hydroxycholesterol. In the presentstudy, we have examined the effect of 7 beta -hydroxycholesterol on cellular redox status and heat shock protein70 (hsp70) expression. Murine peritoneal macrophages were incubated for 24 hours with increasing concentrations of 7 beta -hydroxycholesterol (0-25 mug/ml). Intracellular reduced glutathione levels decreased and oxidized glutathione levels increased, thus increasing the redox ratio. Hsp70 expression in macrophages decreased in a dose-dependent fashion. It is suggested that 7 beta -hydroxycholesterol exerts oxidative stress on macrophages and makes them more susceptible to its proatherogenic effects by impairing the cellular defense system consisting of antioxidants and stress proteins. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:06:37