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Titolo:
Evolution in the practice of primary angioplasty: Effect of adjunctive coronary stenting and glycoprotein IIb/IIIa inhibitors on long-term outcomes
Autore:
Kalaria, VG; Chaudhary, I; Jacobson, S; Pomerantz, RM; Cove, CJ; Ling, FS; Cutlip, DE;
Indirizzi:
Univ Rochester, Med Ctr, Dept Med, Cardiol Unit, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 rdiol Unit, Rochester, NY 14642 USA
Titolo Testata:
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
fascicolo: 3, volume: 54, anno: 2001,
pagine: 327 - 332
SICI:
1522-1946(200111)54:3<327:EITPOP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; IMMEDIATE ANGIOPLASTY; THROMBOLYTIC THERAPY; ARTERY; TRIAL; IMPLANTATION; PLACEMENT; BLOCKADE; FLOW;
Keywords:
myocardial infarction; coronary angioplasty;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Cutlip, DE Beth Israel Deaconess Med Ctr, Intervent Cardiol Sect, 330 Brookline Ave, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr 330 BrooklineAve Boston MA USA 02215
Citazione:
V.G. Kalaria et al., "Evolution in the practice of primary angioplasty: Effect of adjunctive coronary stenting and glycoprotein IIb/IIIa inhibitors on long-term outcomes", CATHET C IN, 54(3), 2001, pp. 327-332

Abstract

Primary angioplasty strategies have evolved dramatically, including increasing adjunctive use of stents and glycoprotein (GP) IIb/IIIa inhibitors. The purpose of this study was to examine the specific effects of these adjunctive therapies on long-term outcomes after primary angioplasty. From 1996 to 1998, 257 unselected, consecutive patients underwent primary PTCI at our institution. In-hospital mortality was 5.4% (2.9% for patients without cardiogenic shock). The remaining 243 patients were followed for 2.0 +/- 0.7 years. Adjunctive stenting was associated with increased late mortality (8.7%vs. 2.3%, P = 0.02). GP IIb/IIIa inhibitors were associated with reduced late mortality among patients receiving stents (6.9% vs. 21.4%, P = 0.07), but not in those patients treated with balloon angioplasty alone (2.9% vs. 0%, P > 0.20). Coronary stenting remained a significant predictor of late mortality (hazard ratio 5.6, 95% CI 1.5-21.2) after adjustment for other established risk factors. In this unselected series, adjunctive coronary stenting was associated with higher late mortality among hospital discharge survivors. Concomitant GP IIb/IIIa inhibitors partially corrected for this increase. These results are limited by the small sample size and retrospective design of this study. Additional long-term studies are required to test these findings and evaluate for possible mechanisms. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:24:29