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Titolo:
The incidence of trisomy 8 as a sole chromosomal aberration in myeloid malignancies varies in relation to gender, age, prior iatrogenic genotoxic exposure, and morphology
Autore:
Paulsson, K; Sall, T; Fioretos, T; Mitelman, F; Johansson, B;
Indirizzi:
Univ Lund Hosp, Dept Clin Genet, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 pt Clin Genet, SE-22185 Lund, Sweden Lund Univ, Dept Genet, SE-22362 Lund, Sweden Lund Univ Lund Sweden SE-22362 d Univ, Dept Genet, SE-22362 Lund, Sweden
Titolo Testata:
CANCER GENETICS AND CYTOGENETICS
fascicolo: 2, volume: 130, anno: 2001,
pagine: 160 - 165
SICI:
0165-4608(20011015)130:2<160:TIOT8A>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE NONLYMPHOCYTIC LEUKEMIA; BRITISH COOPERATIVE GROUP; MYELODYSPLASTIC SYNDROMES; BALANCED REARRANGEMENTS; PROGNOSTIC-SIGNIFICANCE; ABNORMALITIES; CANCER; AML; CLASSIFICATION; TRANSLOCATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Paulsson, K Univ Lund Hosp, Dept Clin Genet, SE-22185 Lund, Sweden Univ Lund Hosp Lund Sweden SE-22185 t, SE-22185 Lund, Sweden
Citazione:
K. Paulsson et al., "The incidence of trisomy 8 as a sole chromosomal aberration in myeloid malignancies varies in relation to gender, age, prior iatrogenic genotoxic exposure, and morphology", CANC GENET, 130(2), 2001, pp. 160-165

Abstract

Although trisomy 8 as a sole change is one of the most common chromosomal abnormalities in myeloid malignancies, it is largely unknown if the incidence of this aberration is influenced by other factors of clinical importance. In the present study, the frequencies of isolated +8 in relation to gender, age, previous treatment with chemo- or radiotherapy, and morphologic subtype were ascertained in published, as well as in our own unpublished, cases of acute myeloid leukemia (AML; n=4,246), myelodysplastic syndromes (MDS;n=1,817), and chronic myeloproliferative disorders (MPD; n=530). The frequencies of +8 were higher in MDS and MPD than in AML (7.5% vs. 5.6%; P <0.01) and varied among the morphologic subtypes of AML and MDS (P <0.001 and P <0.05, respectively). Trisomy 8 was more common in women than in men with MPD (11% vs. 5.1%; P <0.05). Furthermore, the frequencies of +8 were higher in de novo AML and MDS than in treatment-related cases (6.0% vs. 2.8%; P <0.01 and 8.6% vs. 1.5%; P <0.001, respectively). The incidence also varied significantly with age in AML (P <0.001), being more common in elderly patients. Although the causes for this frequency heterogeneity remain to be elucidated, possible explanations may include different environmental exposuresaffecting the origin of +8 in AML, MDS, and MPD and the presence of different underlying cryptic primary aberrations. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:42:51