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Titolo:
Regional mapping of suppressor loci for anchorage independence and tumorigenicity on human chromosome 9
Autore:
Eklund, LK; Islam, K; Soderkvist, P; Islam, MQ;
Indirizzi:
Linkoping Univ, Fac Hlth Sci, Div Cell Biol, Dept Biomed & Surg,Lab Canc Genet, S-58185 Linkoping, Sweden Linkoping Univ Linkoping Sweden S-58185 Genet, S-58185 Linkoping, Sweden
Titolo Testata:
CANCER GENETICS AND CYTOGENETICS
fascicolo: 2, volume: 130, anno: 2001,
pagine: 118 - 126
SICI:
0165-4608(20011015)130:2<118:RMOSLF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DINUCLEOTIDE REPEAT POLYMORPHISM; CUTANEOUS MALIGNANT-MELANOMA; TUMOR SUPPRESSION; HOMOZYGOUS DELETION; FUNCTIONAL EVIDENCE; FAMILIAL MELANOMA; BLADDER-CANCER; CELL CARCINOMA; INK4A LOCUS; NUDE MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Islam, MQ Linkoping Univ, Fac Hlth Sci, Div Cell Biol, Dept Biomed & Surg,Lab Canc Genet, S-58185 Linkoping, Sweden Linkoping Univ Linkoping SwedenS-58185 8185 Linkoping, Sweden
Citazione:
L.K. Eklund et al., "Regional mapping of suppressor loci for anchorage independence and tumorigenicity on human chromosome 9", CANC GENET, 130(2), 2001, pp. 118-126

Abstract

By micro cell-mediated chromosome transfer to the malignant Syrian hamstercell line BHK-191-5C, we previously identified two suppressor functions onhuman chromosome 9 (HSA9), one for anchorage independence and another for tumorigenicity. However, the precise chromosomal locations of these suppressor functions were not determined. The present study was undertaken to define the regional location of these suppressor loci using a panel of microcell hybrids containing structurally altered HSA9 with different deleted regions in the BHK-191-5C background. DNA derived from the cell hybrids was analyzed by PCR for verification of the presence of HSA9 genetic material by amplifying 62 microsatellite markers and 13 genes, covering the entire lengthof HSA9. Our deletion mapping data on anchorage independent and tumorigenic hybrids suggest that the suppressor function for anchorage independence is located in the region between 9q32 to 9qter. The suppressor for tumorigenicity may be located in one of three deleted regions on HSA9, the first onebetween the markers D9S162 and D9S1870, the second one between the markersD9S1868 and TIGRA002I21, and the third one between the markers D9S59 and D9S155. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:36:58