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Titolo:
Nicotine administration reduces striatal MPP plus levels in mice
Autore:
Quik, M; Di Monte, DA;
Indirizzi:
Parkinsons Inst, Sunnyvale, CA 94089 USA Parkinsons Inst Sunnyvale CA USA94089 sons Inst, Sunnyvale, CA 94089 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 917, anno: 2001,
pagine: 219 - 224
SICI:
0006-8993(20011102)917:2<219:NARSMP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIGROSTRIATAL DOPAMINE NEURONS; PARKINSONS-DISEASE; MONOAMINE-OXIDASE; MPTP NEUROTOXICITY; CIGARETTE-SMOKING; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEUROTOXICITY; GLUTAMATE CYTOTOXICITY; TREATMENT COUNTERACTS; NEUROTROPHIC FACTORS; INDUCED PROTECTION;
Keywords:
nicotine; MPP+; C57B1/6 mouse; MPTP; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Quik, M Parkinsons Inst, 1170 Morse Ave, Sunnyvale, CA 94089 USA Parkinsons Inst 1170 Morse Ave Sunnyvale CA USA 94089 CA 94089 USA
Citazione:
M. Quik e D.A. Di Monte, "Nicotine administration reduces striatal MPP plus levels in mice", BRAIN RES, 917(2), 2001, pp. 219-224

Abstract

Nicotine administration has previously been shown to attenuate nigrostriatal damage in animal models of Parkinson's disease, including the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse. The present experiments were done to determine whether nicotine may be exerting its effects by altering striatal levels of 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of MPTP. Mice were injected with nicotine (0.33-1 mg/kg i.p.) 10 min prior to MPTP (30 mg/kg s.c.) followed by three subsequent doses of nicotine at 15-min intervals according to a dose schedule previously shown to be neuroprotective. The mice were sacrificed 1.5, 4 and 8 h after MPTP administration and striatal MPP+ levels measured. Nicotine administration (0.33-1.0 mg/kg) resulted in a time-dependent decline in striatal MPP+ levelsthat was significantly enhanced over that in saline injected animals. Experiments done to examine the effect of age showed that the decrease was observed in older (8-10 months) but not young (6-8 weeks) mice, a finding whichmay explain some of the variability in the effect of nicotine in the MPTP-induced model of nigrostriatal degeneration. In summary, these results suggest that nicotine may exert its neuroprotective action against nigrostriatal degeneration, at least in part, by decreasing striatal MPP+ levels. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:38:57