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Titolo:
Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women: Study of osteoporotic fractures
Autore:
Chapurlat, RD; Bauer, DC; Cummings, SR;
Indirizzi:
Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
BONE
fascicolo: 4, volume: 29, anno: 2001,
pagine: 381 - 387
SICI:
8756-3282(200110)29:4<381:ABEHAS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREDICT HIP FRACTURE; ELDERLY WOMEN; POSTMENOPAUSAL WOMEN; BIOCHEMICAL MARKERS; SERUM ESTRADIOL; I COLLAGEN; RISK; ESTROGEN; RESORPTION; THERAPY;
Keywords:
biochemical markers of bone turnover; estradiol; sex hormone-binding globulin (SHBG) osteoporosis; bone formation; bone resorption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Chapurlat, RD Edouard Herriot Hosp, Dept Rheumatol & Bone Dis, Pavill F, F-69437 Lyon 3,France Edouard Herriot Hosp Pavill F Lyon France 3 7 Lyon 3,France
Citazione:
R.D. Chapurlat et al., "Association between endogenous hormones and sex hormone-binding globulin and bone turnover in older women: Study of osteoporotic fractures", BONE, 29(4), 2001, pp. 381-387

Abstract

Estrogen therapy decreases bone remodeling, but the association between endogenous estradiol (E-2), estrone (E-1), testosterone (T), and bone turnover in older women is not clear. To test the association of serum E-2, E-1, free T, and sex hormone-binding globulin (SHBG) with bone turnover, we analyzed cross-sectional relationships among E-2, E-1, T, SHBG, and biochemical markers of bone turnover serum osteocalcin [OC], serum bone-specific alkaline phosphatase [bAP], and serum breakdown products of C telopeptide of typeI collagen [CTx] in 704 women enrolled in the Study of Osteoporotic Fractures. Women with lower estradiol levels tended to have higher levels of boneturnover, but the association was weak (R-2 = 0.01 for the association E-2-OC, P = 0.03; and R-2 = 0.024 for E-2-CTx, p = 0.001). Relationships between SHBG and turnover were also weak (R-2 for the association SHBG-OC was 0.07, p < 0.001, and 0.03 for SHBG-sCTx, p = 0.03), or not significant (R-2 <0.01 for the association SHBG-bAP). Associations of E-1 and T with these markers were of the same magnitude. These results were not modified after adjustment for age, weight, and smoking status. We conclude that older women with low endogenous hormones have somewhat higher bone turnover, but these associations are weak. Bone turnover is determined mainly by factors other than endogenous concentrations of sex hormones. (Bone 29:381-387; 2001) (C)2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:33:25