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Titolo:
Antimutagenic activity against Trp-P-1 of the edible Thai plant, Oroxylum indicum Vent.
Autore:
Nakahara, K; Onishi-Kameyama, M; Ono, H; Yoshida, M; Trakoontivakorn, G;
Indirizzi:
Japan Int Res Ctr Agr Sci, Tsukuba, Ibaraki 3058686, Japan Japan Int Res Ctr Agr Sci Tsukuba Ibaraki Japan 3058686 ki 3058686, Japan Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan Natl Food Res Inst Tsukuba Ibaraki Japan 3058642 , Ibaraki 3058642, Japan Kasetsart Univ, Inst Food Res & Prod Dev, Bangkok 10903, Thailand Kasetsart Univ Bangkok Thailand 10903 Prod Dev, Bangkok 10903, Thailand
Titolo Testata:
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
fascicolo: 10, volume: 65, anno: 2001,
pagine: 2358 - 2360
SICI:
0916-8451(200110)65:10<2358:AAATOT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCUTELLARIA-BAICALENSIS; METABOLIC-ACTIVATION; HETEROCYCLIC AMINES; INHIBITION; FLAVONOIDS; MUTAGENICITY; CARCINOGEN;
Keywords:
antimutagenicity; Oroxylum indicum Vent.; flavonoid; baicalein; Trp-P-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Nakahara, K Japan Int Res Ctr Agr Sci, 1-1 Ohwashi, Tsukuba, Ibaraki 3058686, Japan Japan Int Res Ctr Agr Sci 1-1 Ohwashi Tsukuba Ibaraki Japan 3058686
Citazione:
K. Nakahara et al., "Antimutagenic activity against Trp-P-1 of the edible Thai plant, Oroxylum indicum Vent.", BIOS BIOT B, 65(10), 2001, pp. 2358-2360

Abstract

A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC50 value of 2.78 +/- 0.15 muM. The potent antimutagenicity of the extract was correlated with the high content (3.95 +/-0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:04:52