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Titolo:
Effects of macrophage colony-stimulating factor on antifungal activity of neonatal monocytes against Candida albicans
Autore:
Gioulekas, E; Goutzioulis, M; Farmakis, C; Drossou, V; Kremenopoulos, G; Tsiouris, J; Roilides, E;
Indirizzi:
Aristotelian Univ Thessaloniki, Hippokration Hosp, Dept Pediat 3, GR-54642Thessaloniki, Greece Aristotelian Univ Thessaloniki Thessaloniki Greece GR-54642 niki, Greece Aristotelian Univ Thessaloniki, Hippokration Hosp, Dept Obstet Gynecol 4, GR-54642 Thessaloniki, Greece Aristotelian Univ Thessaloniki ThessalonikiGreece GR-54642 niki, Greece Aristotelian Univ Thessaloniki, Hippokration Hosp, Dept Neonatol, GR-54642Thessaloniki, Greece Aristotelian Univ Thessaloniki Thessaloniki Greece GR-54642 niki, Greece
Titolo Testata:
BIOLOGY OF THE NEONATE
fascicolo: 4, volume: 80, anno: 2001,
pagine: 251 - 256
SICI:
0006-3126(2001)80:4<251:EOMCFO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIRTH-WEIGHT INFANTS; BLOOD MONONUCLEAR-CELLS; DISSEMINATED FUNGAL-INFECTIONS; CORD-BLOOD; INTERFERON-GAMMA; CYTOKINE PRODUCTION; MURINE MACROPHAGES; PHAGOCYTOSIS; NEWBORN; EXPRESSION;
Keywords:
Candida albicans; fungal immunity; macrophage colony-stimulating factor; monocytes; neonates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Roilides, E Aristotelian Univ Thessaloniki, Hippokration Hosp, Dept Pediat3, 49 Konstantinoupoleos St, GR-54642 Thessaloniki, Greece Aristotelian Univ Thessaloniki 49 Konstantinoupoleos St Thessaloniki Greece GR-54642
Citazione:
E. Gioulekas et al., "Effects of macrophage colony-stimulating factor on antifungal activity of neonatal monocytes against Candida albicans", BIOL NEONAT, 80(4), 2001, pp. 251-256

Abstract

The effects of recombinant macrophage-colony stimulating factor (M-CSF) onantifungal activities of monocytes (MNC) from healthy neonates and adults against Candida albicans were compared. Pretreatment of adult and neonatal MNC with 15 ng/ml of M-CSF for 4 days significantly increased superoxide anion (O-2(-)) production in response to phorbol myristate acetate. While M-CSF-treated MNC from adults produced significantly higher O-2(-) in responseto Candida blastoconidia, M-CSF-treated neonatal MNC did not show a similar response. Further, M-CSF significantly enhanced phagocytosis of C. albicans by adult MNC but not by neonatal MNC. While M-CSF enhances antifungal activities of adult MNC against C. albicans, it does not appear to affect anticandidal function of neonatal MNC. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:45:22