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Titolo:
Chemokine-induced secretion of gelatinase B in primary human monocytes
Autore:
Klier, CM; Nelson, EL; Cohen, CD; Horuk, R; Schlondorff, D; Nelson, PJ;
Indirizzi:
Univ Munich, Med Poliklin, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 Med Poliklin, D-80336 Munich, Germany Univ Calif Irvine, Dept Med, Div Hematol & Oncol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 matol & Oncol, Irvine, CA 92697 USA Berlex Biosci, Richmond, CA 94305 USA Berlex Biosci Richmond CA USA 94305Berlex Biosci, Richmond, CA 94305 USA
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 9, volume: 382, anno: 2001,
pagine: 1405 - 1410
SICI:
1431-6730(200109)382:9<1405:CSOGBI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATRIX METALLOPROTEINASES; TISSUE INHIBITORS; INFLAMMATION; ACTIVATION; MECHANISMS; METASTASIS; MIGRATION; INVASION; RELEASE; RANTES;
Keywords:
BX471; CCR1; CXCR4; MMP-9; RANTES; TIMP-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Nelson, PJ Univ Munich, Med Poliklin, D-80336 Munich, Germany Univ MunichMunich Germany D-80336 n, D-80336 Munich, Germany
Citazione:
C.M. Klier et al., "Chemokine-induced secretion of gelatinase B in primary human monocytes", BIOL CHEM, 382(9), 2001, pp. 1405-1410

Abstract

Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited proteolysis of basement membranes and matrix material. The effect of the chemokines RANTES/CCL5, MCP-1/CCL and SDF-1 /CXCL12 on secretion of the matrix metalloproteinase B and its endogenous inhibitor TIMP-1 was studied. RANTES/CCL5 and SDF-1/CXCL12 were found to induce MMP-9 secretion in primary human monocytes while TIMP-1 secretion was not affected. RANTES/CCL5 effects were mediated through CCR1 because the CCR1 antagonist BX471 was found to effectively block RANTES/CCL5-induced MMP-9 secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:10:44