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Titolo:
Adhesion via CD43 induces Syk activation and cell proliferation in TF-1 cells
Autore:
Miura, Y; Mizutani, C; Nishihara, T; Hishita, T; Yanagi, S; Tohyama, Y; Ichiyama, S; Yamamura, H; Uchiyama, T; Tohyama, K;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Lab Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 t Lab Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 l & Oncol, Sakyo Ku, Kyoto 6068507, Japan Kobe Univ, Grad Sch Med, Dept Genome Sci, Div Proteom,Chuo Ku, Kobe, Hyogo6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 eom,Chuo Ku, Kobe, Hyogo6500017, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 288, anno: 2001,
pagine: 80 - 86
SICI:
0006-291X(20011019)288:1<80:AVCISA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC PROGENITOR CELLS; WISKOTT-ALDRICH SYNDROME; TYROSINE KINASE; MONOCLONAL-ANTIBODY; CROSS-LINKING; SIALOPHORIN; GROWTH; BINDS; LINE;
Keywords:
Syk; CD43; cell proliferation; Erk; TF-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Tohyama, K Kyoto Univ, Grad Sch Med, Dept Lab Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Sakyo Ku, Kyoto 6068507, Japan
Citazione:
Y. Miura et al., "Adhesion via CD43 induces Syk activation and cell proliferation in TF-1 cells", BIOC BIOP R, 288(1), 2001, pp. 80-86

Abstract

The effect of adhesion via CD43 (leukosialin, sialophorin) on cell proliferation and phosphorylation signaling were examined in a growth factor-dependent hematopoietic progenitor cell line, TF-1. TF-1 cells promptly resultedin death after withdrawal of growth factors. However, the viable cell number increased when TF-1 cells were cultured on anti-CD43 monoclonal antibody-coated plates. In this case, sustained activation of protein tyrosine kinase Syk and extracellular signal-regulated kinase (Erk) 1/2 were detected. Overexpression of exogenous Syk on TF-1 cells by the adenovirus vector system induced enhancement of the cell proliferation accompanied with enhancement of the Erk activation by a dominant-positive effect. The signal transducer and activator of transcription (STAT) 5 seemed not to be associated with the CD43-mediated cell proliferation. These results indicated that adhesionvia CD43 induces the proliferation of TF-1 cells in the absence of growth factors in part by Syk-dependent Erk 1/2 signaling. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:01:04