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Titolo:
Pervasive developmental disorder and obstetric complications in children and adolescents with tuberous sclerosis
Autore:
Park, RJ; Bolton, PF;
Indirizzi:
Univ Cambridge, Dept Psychiat, Dev Psychiat Sect, Autism & Related Condit Res Ctr, Cambridge CB3 9JE, England Univ Cambridge Cambridge England CB3 9JE Ctr, Cambridge CB3 9JE, England
Titolo Testata:
AUTISM
fascicolo: 3, volume: 5, anno: 2001,
pagine: 237 - 248
SICI:
1362-3613(200109)5:3<237:PDDAOC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC TUMORS; AUTISM; IDENTIFICATION; POPULATION; PREGNANCY; DIAGNOSIS; BEHAVIOR; FETAL; GENE; 9Q34;
Keywords:
cognitive development; obstetric complications; pervasive developmental disorder; tuberous sclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Park, RJ Univ Cambridge, Dept Psychiat, Dev Psychiat Sect, Autism & Related Condit Res Ctr, 18B Trumpington Rd, Cambridge CB3 9JE, England Univ Cambridge 18B Trumpington Rd Cambridge England CB3 9JE land
Citazione:
R.J. Park e P.F. Bolton, "Pervasive developmental disorder and obstetric complications in children and adolescents with tuberous sclerosis", AUTISM, 5(3), 2001, pp. 237-248

Abstract

Children with autism have an increased risk for obstetric complications but it is not known whether these are of primary aetiological significance. It is also unclear whether obstetric complications play a secondary role in shaping phenotypic expression in individuals at genetic risk for autism. Weinvestigated this question by studying the role of obstetric complicationsin determining phenotypic manifestations in tuberous sclerosis, a single gene disorder frequently associated with autism spectrum disorders. Obstetric histories of 43 children with non-familial TS and 40 unaffected siblings were obtained using a structured parent interview. ADI-R, ADOS-G and IQ evaluations were undertaken. Children with TS experienced more obstetric complications than their unaffected siblings, but these were related to mild rather than severe adversities. No differences in obstetric complications werefound in children with and without autism spectrum disorders and there wasno positive correlation between obstetric adversities and severity of autism spectrum disorders or intellectual impairments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:33:09