Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders
Autore:
Cataldo, A; Rebeck, GW; Ghetti, B; Hulette, C; Lippa, C; Van Broeckhovan, C; van Duijn, C; Cras, P; Bogdanovic, N; Bird, T; Peterhoff, C; Nixon, R;
Indirizzi:
Harvard Univ, McLean Hosp, Sch Med, Mailman Res Ctr,Lab Mol Neuropathol, Belmont, MA 02478 USA Harvard Univ Belmont MA USA 02478 Mol Neuropathol, Belmont, MA 02478 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Alzheimers Res Ctr, Charlestown, MA USA Harvard Univ Charlestown MA USA Alzheimers Res Ctr, Charlestown, MA USA Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Pathol, Indianapolis, IN 46202 USA Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Pathol, Durham, NC 27710 USA Med Coll Penn & Hahnemann Univ, Dept Neurol, Philadelphia, PA 19102 USA Med Coll Penn & Hahnemann Univ Philadelphia PA USA 19102 ia, PA 19102 USA Univ Antwerp, Born Bunge Fdn, Flanders Interuniv Inst Biotechnol, Dept MolGenet, B-2020 Antwerp, Belgium Univ Antwerp Antwerp Belgium B-2020 pt MolGenet, B-2020 Antwerp, Belgium Erasmus Univ, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Univ Antwerp, Born Bunge Fdn, Neurobiol Lab, B-2020 Antwerp, Belgium Univ Antwerp Antwerp Belgium B-2020 urobiol Lab, B-2020 Antwerp, Belgium Karolinska Inst, Dept Geriatr Med, Inst Clin Neurosci & Family Med, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 Med, S-10401 Stockholm, Sweden VA Med Ctr, Dept Geriatr, Seattle, WA USA VA Med Ctr Seattle WA USAVA Med Ctr, Dept Geriatr, Seattle, WA USA Nathan S Kline Inst Psychiat Res, Ctr Dermatia Res, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res Orangeburg NY USA 10962 rg, NY 10962 USA NYU, Sch Med, Dept Psychiat, New York, NY USA NYU New York NY USANYU, Sch Med, Dept Psychiat, New York, NY USA NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA NYU New York NY USA 10016 Sch Med, Dept Cell Biol, New York, NY 10016 USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 5, volume: 50, anno: 2001,
pagine: 661 - 665
SICI:
0364-5134(200111)50:5<661:EDDASO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; BETA-SECRETASE CLEAVAGE; APOE GENOTYPE; ENDOPLASMIC-RETICULUM; DOWN-SYNDROME; ONSET; MUTATION; PATHWAY; ALLELE; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Cataldo, A Harvard Univ, McLean Hosp, Sch Med, Mailman Res Ctr,Lab Mol Neuropathol, 115 Mill St, Belmont, MA 02478 USA Harvard Univ 115 Mill St Belmont MA USA 02478 ont, MA 02478 USA
Citazione:
A. Cataldo et al., "Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders", ANN NEUROL, 50(5), 2001, pp. 661-665

Abstract

The endocytic pathway is important in amyloid precursor protein (APP) processing and beta -amyloid formation. Our studies have shown that endocytic pathway activation is a prominent and early feature of neurons in vulnerableregions of the brain in sporadic Alzheimer's disease. We report that endocytic pathway abnormalities are present not only in neurons, but in cerebralendothelia in Alzheimer's disease caused by certain APP mutations. The presence or absence of endocytic abnormalities distinguish subtypes of familial Alzheimer's disease linked to APP mutations from presenilin mutations, supporting the notion that different cellular pathways are involved in the altered processing of APP leading to increased beta -amyloid generation in certain of these different Alzheimer's disease subtypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:52:13