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Titolo:
Case-control study of the extended tau gene haplotype in Parkinson's disease
Autore:
Maraganore, DM; Hernandez, DG; Singleton, AB; Fatter, MJ; McDonnell, SK; Hutton, ML; Hardy, JA; Rocca, WA;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 urol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA Mayo Clin& Mayo Fdn Rochester MN USA 55905 Res, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Mol Genet Lab, Jacksonville, FL USA Mayo Clin & MayoFdn Jacksonville FL USA Genet Lab, Jacksonville, FL USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 5, volume: 50, anno: 2001,
pagine: 658 - 661
SICI:
0364-5134(200111)50:5<658:CSOTET>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Maraganore, DM Mayo Clin & Mayo Fdn, Dept Neurol, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 A
Citazione:
D.M. Maraganore et al., "Case-control study of the extended tau gene haplotype in Parkinson's disease", ANN NEUROL, 50(5), 2001, pp. 658-661

Abstract

We investigated the association of Parkinson's disease with tau gene haplotypes. In a sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0.98-2.23); however, the finding was not statistically significant. The results remained similar after adjusting for the possible misclassification of progressive supranuclear palsy patients as Parkinson's disease, but became statistically significant after restricting the analysis to nondemented subjects.

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Documento generato il 25/01/20 alle ore 16:00:16