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Titolo:
Human herpesvirus 6 limbic encephalitis after stem cell transplantation
Autore:
Wainwright, MS; Martin, PL; Morse, RP; Lacaze, M; Provenzale, JM; Coleman, E; Morgan, MA; Hulette, C; Kurtzberg, J; Bushnell, C; Epstein, L; Lewis, DV;
Indirizzi:
Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Pediat, Durham, NC 27710 USA Northwestern Univ, Sch Med, Childrens Mem Hosp, Div Pediat Neurol, Chicago, IL USA Northwestern Univ Chicago IL USA osp, Div Pediat Neurol, Chicago, IL USA Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 iv, Med Ctr, Dept Med, Durham, NC 27710 USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 5, volume: 50, anno: 2001,
pagine: 612 - 619
SICI:
0364-5134(200111)50:5<612:HH6LEA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; VERSUS-HOST DISEASE; RESONANCE-IMAGING EVIDENCE; CENTRAL NERVOUS-SYSTEM; NEUROLOGIC COMPLICATIONS; FATAL ENCEPHALITIS; EPILEPTIFORM ACTIVITY; FEBRILE CONVULSIONS; PARTIAL EPILEPSY; HHV-6 INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lewis, DV Duke Univ, Med Ctr, Dept Pediat, Box 3696, Durham, NC 27710 USA Duke Univ Box 3696 Durham NC USA 27710 696, Durham, NC 27710 USA
Citazione:
M.S. Wainwright et al., "Human herpesvirus 6 limbic encephalitis after stem cell transplantation", ANN NEUROL, 50(5), 2001, pp. 612-619

Abstract

Central nervous system complications are common in stem cell transplant recipients, but selective involvement of the medial temporal area is unusual. The 5 patients reported here presented after stem cell transplantation with increased hippocampal T2 signal on magnetic resonance imaging and increased hippocampal glucose uptake on [F-18]fluorodeoxyglucose-positron emissiontomography (FDG-PET) associated with short-term memory loss, insomnia, andtemporal lobe electrographic seizure activity. The initial scalp electroencephalograms (EEGs) failed to detect seizure activity in these patients, although the memory dysfunction along with the magnetic resonance imaging andFDG-PET findings suggested subcortical seizure activity. However, extendedEEG monitoring revealed repetitive temporal lobe electrographic seizure activity. Follow-up MRIs in 2 patients and postmortem findings on 1 patient suggested that hippocampal sclerosis had developed following the clinical syndrome. Cerebrospinal fluid studies revealed the presence of human herpesvirus 6, variant B, DNA in all of 3 patients who had lumbar punctures. Immunohistochemical staining for the P41 and P101 human herpesvirus 6 protein antigens showed numerous immunoreactive astrocytes and neurons in the hippocampus of 1 of the patients who died from other causes. Because of its subtle clinical presentation, this syndrome may be underrecognized, but can be diagnosed with appropriate magnetic resonance imaging techniques, EEG monitoring, and cerebrospinal fluid viral studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:43:58