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Titolo:
Attention and cognition in bradykinetic-rigid syndromes: An event-related potential study
Autore:
Pirtosek, Z; Jahanshahi, M; Barrett, G; Lees, AJ;
Indirizzi:
Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England Natl Hosp Neurol & Neurosurg London England WC1N 3BG n WC1N 3BG, England Inst Neurol, MRC, Human Movement & Balance Unit, London WC1N 3BG, England Inst Neurol London England WC1N 3BG lance Unit, London WC1N 3BG, England
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 5, volume: 50, anno: 2001,
pagine: 567 - 573
SICI:
0364-5134(200111)50:5<567:AACIBS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; PARKINSONS-DISEASE; ELECTROPHYSIOLOGICAL DIFFERENCES; DEFICITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Pirtosek, Z Univ Med Ctr, Inst Clin Neurophysiol, SI-1525 Ljubljana, Slovenia Univ Med Ctr Ljubljana Slovenia SI-1525 Ljubljana, Slovenia
Citazione:
Z. Pirtosek et al., "Attention and cognition in bradykinetic-rigid syndromes: An event-related potential study", ANN NEUROL, 50(5), 2001, pp. 567-573

Abstract

Bradykinetic-rigid syndromes are often accompanied by cognitive impairment. Because prominent motor involvement in these disorders may interfere withneuropsychological testing, we used event-related potentials (ERPs) for the assessment of cognition and attention in 41 patients with various bradykinetic-rigid syndromes of less than 5 years duration: idiopathic Parkinson'sdisease corticobasal degeneration, Steele-Richardson-Olszewski syndrome (SRO), and multiple system atrophy. Patients were compared with matched normals. ERP abnormalities in the auditory "oddball" paradigm were found only incorticobasal degeneration and SRO. ERP abnormalities in selective attention tasks were present in all patient groups, changes in SRO being the most prevalent. Abnormalities in corticobasal degeneration were present under "less-attention-demanding" conditions and suggested involvement of posterior parts of the brain. Multiple system atrophy and idiopathic Parkinson's disease patient groups had minimal ERP abnormalities. However, reaction times inMSA were longer in all paradigms. The results of the study support the view that bradykinetic-rigid syndromes involve some attentional deficits, but also have distinct reaction time and ERP characteristics, which may be helpful in differential diagnosis.

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Documento generato il 19/01/20 alle ore 15:14:36