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Titolo:
Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute stroke
Autore:
Hillis, AE; Wityk, RJ; Tuffiash, E; Beauchamp, NJ; Jacobs, MA; Barker, PB; Selnes, OA;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Radiol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Cognit Sci, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA , Dept Cognit Sci, Baltimore, MD USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 5, volume: 50, anno: 2001,
pagine: 561 - 566
SICI:
0364-5134(200111)50:5<561:HOWAPS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSION-WEIGHTED MRI; ACUTE ISCHEMIC STROKE; CEREBRAL BLOOD-FLOW; WORD COMPREHENSION; DIFFUSION; KNOWLEDGE; VOLUME; ANATOMY; REGIONS; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Hillis, AE Johns Hopkins Univ Hosp, Dept Neurol, Meyer 5-185,600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Univ Hosp Meyer 5-185,600 N Wolfe St Baltimore MD USA 21287
Citazione:
A.E. Hillis et al., "Hypoperfusion of Wernicke's area predicts severity of semantic deficit in acute stroke", ANN NEUROL, 50(5), 2001, pp. 561-566

Abstract

Based on earlier findings that the presence of word comprehension impairment (a deficit in the meaning of words, or lexical semantics) in acute stroke was strongly associated with the presence of hypoperfusion or infarct in Wernicke's area, we tested the hypothesis that the severity of word comprehension impairment was correlated with the magnitude of delay in perfusion of Wernicke's area on magnetic resonance perfusion-weighted imaging. Eighty patients were prospectively studied within 24 hours of onset or progressionof acute left hemisphere stroke symptoms, with diffusion-weighted imaging,perfusion-weighted imaging, and detailed language tests. For 50 patients without infarct in Wernicke's area, we found a strong Pearson correlation between the rate of errors on a word comprehension test and the mean number of seconds of delay in time-to-peak concentration of contrast in Wernicke's area, relative to the homologous region on the right. These results add further evidence for the crucial role of Wernicke's area (Brodmann's area 22) in word comprehension and indicate that the magnitude of delay on PWI may be a gross indicator of tissue dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:40:22