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Titolo:
Relation of Chlamydia pneumoniae infection in Taiwan to angiographically demonstrated coronary artery disease and to the presence of acute myocardialinfarction or unstable angina pectoris
Autore:
Tsai, CT; Kao, JH; Hsu, KL; Chiang, FT; Tseng, CD; Liau, CS; Tseng, YZ; Hwang, JJ;
Indirizzi:
Natl Taiwan Univ Hosp, Dept Internal Med, Cardiol Sect, Taipei 100, TaiwanNatl Taiwan Univ Hosp Taipei Taiwan 100 Cardiol Sect, Taipei 100, Taiwan Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan Natl TaiwanUniv Taipei Taiwan Med, Grad Inst Clin Med, Taipei, Taiwan
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 9, volume: 88, anno: 2001,
pagine: 960 - 963
SICI:
0002-9149(20011101)88:9<960:ROCPII>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROLOGICAL EVIDENCE; IGA ANTIBODIES; HEART-DISEASE; TWAR ANTIBODY; STRAIN TWAR; AZITHROMYCIN; PREVALENCE; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Hwang, JJ Natl Taiwan Univ Hosp, Dept Internal Med, Cardiol Sect, 7 Chung Shan S Rd,Taipei 100, Taiwan Natl Taiwan Univ Hosp 7 Chung Shan S Rd Taipei Taiwan 100 aiwan
Citazione:
C.T. Tsai et al., "Relation of Chlamydia pneumoniae infection in Taiwan to angiographically demonstrated coronary artery disease and to the presence of acute myocardialinfarction or unstable angina pectoris", AM J CARD, 88(9), 2001, pp. 960-963

Abstract

Reports of the association of Chlamydia pneumoniae (C. pneumoniae) infection with coronary artery disease (CAD) are scarce in the Oriental population. We therefore conducted a case-control study to explore this issue in Taiwan. There were 242 consecutive subjects (166 men and 76 women) who underwent cardiac catheterization at the Notional Taiwan University Hospital Cardiac Catheterization Laboratory. Patients with CAD (n = 156) had greater than or equal to1 coronary artery lesion of >50% diameter stenosis on angiography. Controls (n = 86) had no demonstrable CAD angiographically. Antibodies to C. pneumoniae were tested by using an enzyme-linked immunosorbent assay. The prevalence of antibodies to C. pneumoniae was as follows: immunoglobulin-G (IgG), 50% (122 of 242 patients); immunoglobulin-A (IgA), 72% (176 of 242 patients); and either IgG or IgA, 79% (192 of 242 patients). The odds ratio (OR) for CAD with either IgG or IgA was 1.4 (95% confidence interval [CI] 0.7 to 2.7, p = 0.31). After adjusting for the known CAD risk factors, the OR decreased to 0.8 (95% CI 0.3 to 2.1, p = 0.60). The OR for unstable angina or acute myocardial infarction with the presence of either IgG or IgAwas 0.5 (95% CI 0.2 to 1.1, p = 0.08) and 0.4 (95% CI 0.1 to 1.0, p = 0.049) after adjusting for other risk factors. These results suggest a high prevalence of C. pneumoniae infection in Taiwan. However, C. pneumoniae infection is not associated with angiographically documented CAD, and, in contrast, is a negative predictor for the development of acute coronary syndromes. (C)2001 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:24:22