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Titolo:
Persistent bacterial infections and serum activity in chronic urticaria - role of molecular mimicry?
Autore:
Wedi, B; Liekenbrocker, T; Kapp, A;
Indirizzi:
Hannover Med Sch, Klin & Poliklin Dermatol & Venerol, D-30449 Hannover, Germany Hannover Med Sch Hannover Germany D-30449 rol, D-30449 Hannover, Germany
Titolo Testata:
ALLERGOLOGIE
fascicolo: 10, volume: 24, anno: 2001,
pagine: 480 - 490
SICI:
0344-5062(200110)24:10<480:PBIASA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
GER
Soggetto:
HELICOBACTER-PYLORI INFECTION; BETA-D-GLUCOSAMINE; IDIOPATHIC CHRONIC URTICARIA; RI-ALPHA AUTOANTIBODIES; AFFINITY IGE RECEPTOR; ANTIGENIC MIMICRY; HISTAMINE-RELEASE; ANTIBODY-RESPONSE; AUTOLOGOUS SERUM; GASTRIC-MUCOSA;
Keywords:
chronic urticaria; infect; autoimmunity; molecular mimicry; Helicobacter pylori;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Wedi, B Hannover Med Sch, Klin & Poliklin Dermatol & Venerol, Ricklinger Str 5, D-30449 Hannover, Germany Hannover Med Sch Ricklinger Str 5 HannoverGermany D-30449 ermany
Citazione:
B. Wedi et al., "Persistent bacterial infections and serum activity in chronic urticaria - role of molecular mimicry?", ALLERGOLOGI, 24(10), 2001, pp. 480-490

Abstract

Annoying symptoms of chronic urticaria, which are often lasting daily for years or decades, are suggested to be mediated by mast cell and basophil mediator release. However, the exact pathomechanisms of effector cell activation are far from being clear. For the patients, failure to identify a trigger is often the most troubling aspect or the disease. Immunologic mechanisms, i.e. a specific IgE response can not be identified in nearly all of the cases. Therefore, besides pseudoallergic mechanisms persistent bacterial infections (e.g. with streptococci, Helicobacter pylori) and an autoimmune serum activity with production of autoantibodies against IgE and the high affinity IgE receptor Fc epsilon RI alpha as well as against thyroid are discussed to be of pathogenic relevance. On the one side, this review Summarizesthe current knowledge of the pathogenic role of infections (particularly with Helicobacter pylori) in chronic urticaria and their potential association to autoimmune mechanisms. On the other side based on our experience of several years in the care of about 600 patients, a reliable diagnostic procedure for patients with chronic urticaria is presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 00:00:33