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Titolo:
Regional central nervous system densities of delta-opioid receptors in alcohol-preferring P, alcohol-nonpreferring NP, and unselected Wistar rats
Autore:
Strother, WN; Chernet, EJ; Lumeng, L; Li, TK; McBride, WJ;
Indirizzi:
Indiana Univ Sch Med, Inst Psychiat Res, Indianapolis, IN 46202 USA Indiana Univ Sch Med Indianapolis IN USA 46202 Indianapolis, IN 46202 USA Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA Indiana Univ Sch Med Indianapolis IN USA 46202 Indianapolis, IN 46202 USA Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Sch Med Indianapolis IN USA 46202 Indianapolis, IN 46202 USA Indiana Univ Sch Med, Dept Biochem, Indianapolis, IN 46202 USA Indiana Univ Sch Med Indianapolis IN USA 46202 Indianapolis, IN 46202 USA VAMC, Indianapolis, IN 46202 USA VAMC Indianapolis IN USA 46202VAMC, Indianapolis, IN 46202 USA
Titolo Testata:
ALCOHOL
fascicolo: 1, volume: 25, anno: 2001,
pagine: 31 - 38
SICI:
0741-8329(200108)25:1<31:RCNSDO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; AVOIDING ANA RATS; HYPOTHALAMIC BETA-ENDORPHIN; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; ENHANCED SENSITIVITY; ETHANOL-CONSUMPTION; PREFERENTIAL STIMULATION; C57BL/6 MICE; DBA/2 MICE;
Keywords:
autoradiography; [H-3]-DPDPE; delta-opioid receptor; alcohol drinking; selected rat lines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Strother, WN Indiana Univ Sch Med, Inst Psychiat Res, 791 Union Dr, Indianapolis, IN 46202 USA Indiana Univ Sch Med 791 Union Dr Indianapolis IN USA 46202 A
Citazione:
W.N. Strother et al., "Regional central nervous system densities of delta-opioid receptors in alcohol-preferring P, alcohol-nonpreferring NP, and unselected Wistar rats", ALCOHOL, 25(1), 2001, pp. 31-38

Abstract

The densities of delta-opioid receptors in the central nervous system of alcohol-naive, adult, male, alcohol-preferring P, alcohol-nonpreferring NP, and Wistar rats were examined with the use of quantitative autoradiography. Slides with coronal 20-mum sections through the regions of interest were incubated in 5 nM [H-3]-[D-Pen(2),D-Pen(5)]enkephalin (DPDPE) to label delta-opioid receptor sites. Nonspecific binding was determined in the presence of 10 muM naloxone. Significant differences between the P and the NP rat lines were found in numerous cortical regions, the basolateral amygdala, and the posterior hippocampus, with 10%-20% lower [H-3]-DPDPE binding found in the P line. In most regions examined, binding levels in the Wistar rats were intermediate between those of the P and the NP rats. Significantly lower [H-3]-DPDPE binding levels in the P rat may indicate fewer delta(1)-opioid receptors or decreased binding affinity. The lower binding in certain limbic regions, such as the basolateral amygdala and posterior hippocampus, as well as cortical differences in the P rat may be associated with the divergent alcohol drinking behaviors found between the P and the NP lines. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 22/01/20 alle ore 18:38:54