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Titolo:
Effects of naltrexone on the intake of ethanol and flavored solutions in rats
Autore:
Goodwin, FLW; Campisi, M; Babinska, I; Amit, Z;
Indirizzi:
Concordia Univ, Ctr Studies Behav Neurobiol, Montreal, PQ H3G 1M8, Canada Concordia Univ Montreal PQ Canada H3G 1M8 l, Montreal, PQ H3G 1M8, Canada
Titolo Testata:
ALCOHOL
fascicolo: 1, volume: 25, anno: 2001,
pagine: 9 - 19
SICI:
0741-8329(200108)25:1<9:EONOTI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHESUS-MONKEYS; C57BL/6 MICE; ALCOHOL-CONSUMPTION; LOCOMOTOR-ACTIVITY; TASTE REACTIVITY; OPIATE RECEPTORS; SACCHARIN INTAKE; P-RATS; NALOXONE; DRINKING;
Keywords:
ethanol; saccharin; quinine; naltrexone; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Goodwin, FLW Concordia Univ, Ctr Studies Behav Neurobiol, 1455 MaisonneuveBlvd W H-1013, Montreal, PQ H3G 1M8, Canada Concordia Univ 1455 Maisonneuve Blvd W H-1013 Montreal PQ Canada H3G 1M8
Citazione:
F.L.W. Goodwin et al., "Effects of naltrexone on the intake of ethanol and flavored solutions in rats", ALCOHOL, 25(1), 2001, pp. 9-19

Abstract

It has been suggested that the endogenous opioid system may mediate the intake of preferred fluids, perhaps through an attenuation of reinforcement properties causing a subsequent shift in palatability. The purpose of the present study was to investigate the effects of the nonspecific opiate antagonist naltrexone on the intake of 10% ethanol, 0.1% saccharin, 0.0006% quinine, 0.4% saccharin + 10% ethanol, and 0.4% saccharin + 0.04% quinine solutions. Fluid intake was measured in male Long-Evans and Wistar rats under 24-h continuous and 30-min limited-fluid-access drinking paradigms. All rats received injections of naltrexone hydrochloride (10 mg/kg, i.p.) for 5 days after baseline intake measures and were monitored for a further 5 days (after-treatment phase). Results indicated that naltrexone did not affect intake of any solution when fluids were available over 24 h. However, under limited-access conditions, naltrexone caused a decrease in the intake of all fluids except quinine in both rat strains. On the basis of these findings, itis possible that the effects of this dose of naltrexone were not due to any true conditioning effect on the reinforcement properties of ethanol, but perhaps to some nonspecific effect of the drug, such as an alteration in palatability or an attenuation of locomotor activity. As well, due to the inconsistent results in fluid intake across drinking paradigms, the present findings do not provide evidence for an effective role for opiate mediation in ethanol intake as well as any ethanol-sweet fluid intake interactions. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:24:17