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Titolo:
The epicardium as a source of mesenchyme for the developing heart
Autore:
Munoz-Chapuli, R; Perez-Pomares, JA; Macias, D; Garcia-Garrido, L; Carmona, R; Gonzalez-Iriarte, M;
Indirizzi:
Univ Malaga, Fac Sci, Dept Anim Biol, E-29071 Malaga, Spain Univ Malaga Malaga Spain E-29071 , Dept Anim Biol, E-29071 Malaga, Spain
Titolo Testata:
ADVANCES IN MICROANATOMY OF CELLS AND TISSUES, BIOPHYSICAL AND BIOCHEMICALCORRELATES
, volume: 7, anno: 2001,
pagine: 187 - 196
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOGFISH SCYLIORHINUS-CANICULA; DEVELOPING AVIAN HEART; QUAIL-CHICK CHIMERA; SUBEPICARDIAL MESENCHYME; SMOOTH-MUSCLE; ORIGIN; CELLS; EMBRYO; IMMUNOLOCALIZATION; DIFFERENTIATION;
Keywords:
epicardium; epithelial-mesenchymal transition; cardiac development;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Munoz-Chapuli, R Univ Malaga, Fac Sci, Dept Anim Biol, E-29071 Malaga, Spain Univ Malaga Malaga Spain E-29071 E-29071 Malaga, Spain
Citazione:
R. Munoz-Chapuli et al., "The epicardium as a source of mesenchyme for the developing heart", MA MA SY SE, 7, 2001, pp. 187-196

Abstract

The primitive epicardium of the vertebrate embryo has traditionally been regarded as a rather passive mesothelium, lining the embryonic myocardium and forming the adult visceral pericardium. However, in recent years, there is an increasing evidence that the primitive epicardium is a highly dynamic element with supplies cells to the developing heart through a process of epithelial-mesenchymal transition. This process seems to be more active at the atrioventricular canal and outflow tract, i.e. the cardiac segments wherethe endothelium transforms into mesenchyme. In this paper we review the current evidence which supports such epicardial-mesenchymal transition, namely: 1) morphological features, 2) colocalization of cytokeratin and vimentinin the epicardial and subepicardial mesenchymal cells, 3) presence of common antigens in the transforming epicardium and endocardial cushions (fibrillin-2/JB3, ES/130, Ets-1). Recently, we have immunolocated the transcription factor Slug in the developing avian heart. Slug is a zinc-finger protein involved in the formation of the neural crest, a developmental event which implies an epithelial-mesenchymal transition. All cells of the primitive epicardium are Slug(+) from their differentiation until the stage HH24. However, only a fraction of the endothelial cells from the endocardial cushions are Slug(+). We speculate that the expression of Slug marks competence of the epicardial cells to transform into mesenchyme, although this transformation is only achieved where an inducing signal is produced. Regarding the developmental fate of the epicardial-derived cell population, there is strongevidence of its differentiation in fibroblasts and vascular smooth muscle cells, although a contribution to the coronary endothelium cannot be discarded.

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Documento generato il 04/04/20 alle ore 01:56:08