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Titolo:
Caveolae and caveolin-3 in muscular dystrophy
Autore:
Galbiati, F; Razani, B; Lisanti, MP;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Pharmacol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 armacol, Pittsburgh, PA 15261 USA Yeshiva Univ Albert Einstein Coll Med, Albert Einstein Canc Ctr, Bronx, NY10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 onx, NY10461 USA Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 onx, NY 10461USA
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 10, volume: 7, anno: 2001,
pagine: 435 - 441
SICI:
1471-4914(200110)7:10<435:CACIMD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; TARGETED DOWN-REGULATION; ROUS-SARCOMA VIRUS; PLASMA-MEMBRANE; GENE FAMILY; SKELETAL-MUSCLE; IN-VIVO; PROTEIN-COMPONENT; INSULIN-RECEPTOR; SMOOTH-MUSCLE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Lisanti, MP Univ Pittsburgh, Sch Med, Dept Pharmacol, Biomed Sci Tower,Rm E1356, Pittsburgh, PA 15261 USA Univ Pittsburgh Biomed Sci Tower,Rm E1356 Pittsburgh PA USA 15261
Citazione:
F. Galbiati et al., "Caveolae and caveolin-3 in muscular dystrophy", TRENDS MO M, 7(10), 2001, pp. 435-441

Abstract

Caveolae are vesicular invaginations of the plasma membrane, and function as,message centers' for regulating signal transduction events. Caveolin-3, a muscle-specific caveolin-related protein, is the principal structural protein of caveolar membrane domains in skeletal muscle and in the heart. Several mutations within the coding sequence of the human caveolin-3 gene (located at 3p25) have been identified. Mutations that lead to a loss of similarto 95% of caveolin-3 protein expression are responsible for a novel autosomal dominant form of limb-girdle muscular dystrophy (LGMD-1C) in humans. Bycontrast, upregulation of the caveolin-3 protein is associated with Duchenne muscular dystrophy (DMD). Thus, tight regulation of caveolin-3 appears essential for maintaining normal muscle health and homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 00:39:52