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Titolo:
NEMO/IKK gamma: Linking NF-kappa B to human disease
Autore:
Courtois, G; Smahi, A; Israel, A;
Indirizzi:
Inst Pasteur, CNRS, URA 1773, Unite Biol Mol Express Genique, Paris, France Inst Pasteur Paris France Unite Biol Mol Express Genique, Paris, France Hop Necker Enfants Malad, INSERM, Unite Rech Handicaps Genet Enfant, U393,Paris, France Hop Necker Enfants Malad Paris France Genet Enfant, U393,Paris, France
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 10, volume: 7, anno: 2001,
pagine: 427 - 430
SICI:
1471-4914(200110)7:10<427:NGLNBT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOHIDROTIC ECTODERMAL DYSPLASIA; SEVERE LIVER DEGENERATION; X-LINKED DISORDER; INCONTINENTIA PIGMENTI; DEFICIENT MICE; KINASE COMPLEX; IKK COMPLEX; MUTATIONS; PROTEIN; HOMOLOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Courtois, G Inst Pasteur, CNRS, URA 1773, Unite Biol Mol Express Genique, Paris, France Inst Pasteur Paris France ol Express Genique, Paris, France
Citazione:
G. Courtois et al., "NEMO/IKK gamma: Linking NF-kappa B to human disease", TRENDS MO M, 7(10), 2001, pp. 427-430

Abstract

Until recently, no genetic disease caused by NF-kappaB dysfunction was known. This changed with the identification of the X-linked gene encoding a molecule of the NF-kappaB signaling pathway, NEMO/IKK gamma Two distinct X-linked human diseases, incontinentia pigmenti (IP) and anhidrotic ectodermal dysplasia associated with immunodeficiency (EDA-ID), have been linked to NEMO/IKK gamma dysfunction, providing a unique view of the role that NF-kappaB plays in human development, skin homeostasis and innate and acquired immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:13:03