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Titolo:
HLA-G remains a mystery
Autore:
Bainbridge, D; Ellis, S; Le Bouteiller, P; Sargent, I;
Indirizzi:
Univ London Royal Vet Coll, Potters Bar EN6 1NB, Herts, England Univ London Royal Vet Coll Potters Bar Herts England EN6 1NB rts, England Inst Anim Hlth, Compton RG20 7NN, Berks, England Inst Anim Hlth Compton Berks England RG20 7NN on RG20 7NN, Berks, England CHU Purpan, INSERM, U395, F-31024 Toulouse, France CHU Purpan Toulouse France F-31024 NSERM, U395, F-31024 Toulouse, France John Radcliffe Hosp, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU ecol, Oxford OX3 9DU, England
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 10, volume: 22, anno: 2001,
pagine: 548 - 552
SICI:
1471-4906(200110)22:10<548:HRAM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN EXTRAVILLOUS TROPHOBLAST; G MESSENGER-RNA; CLASS-I ANTIGEN; CD94/NKG2 RECEPTORS; PROTEIN EXPRESSION; G POLYMORPHISM; CELL-SURFACE; PREGNANCY; MELANOMA; FORM;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Bainbridge, D Univ London Royal Vet Coll, 44 Hawkshead Rd, Potters Bar EN61NB, Herts, England Univ London Royal Vet Coll 44 Hawkshead Rd Potters BarHerts England EN6 1NB
Citazione:
D. Bainbridge et al., "HLA-G remains a mystery", TRENDS IMMU, 22(10), 2001, pp. 548-552

Abstract

In this brief summary, we argue that many widely held beliefs about HLA-G are questionable. Recent research has led to a re-evaluation of many of thecharacteristics that were thought to make HLA-G unusual among the MHC class I molecules. First, contrary to reports suggesting that the gene encodingHLA-G exhibits marked polymorphism in some human populations, recent data have shown that the HLA-G gene has comparatively little polymorphism-a feature that might allow it to be expressed in the placenta without causing rejection by the maternal immune system. Second, although truncated forms of HLA-G are generated in the placenta, most of them are unlikely to have significant biological effects as they do not reach the cell surface. Third, thehypothesis that a major role of HLA-G is to prevent attack of the placentaby maternal natural killer cells is now the subject of renewed scrutiny. Finally, there is little evidence that the induction of expression of HLA-G is a major mechanism by which tumor cells avoid immune attack. HLA-G has once again become as mysterious as when it was discovered: an MHC class I molecule expressed at a challengingly extraordinary site-the immunologically uneasy interface between mother and fetus.

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Documento generato il 28/03/20 alle ore 23:15:50