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Titolo:
Dosimetry modeling of inhaled formaldehyde: Binning nasal flux predictionsfor quantitative risk assessment
Autore:
Kimbell, JS; Overton, JH; Subramaniam, RP; Schlosser, PM; Morgan, KT; Conolly, RB; Miller, FJ;
Indirizzi:
CIIT Ctr Hlth Res, Res Triangle Pk, NC 27709 USA CIIT Ctr Hlth Res Res Triangle Pk NC USA 27709 Triangle Pk, NC 27709 USA US EPA, Expt Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 & Dev, Res Triangle Pk, NC 27711 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 1, volume: 64, anno: 2001,
pagine: 111 - 121
SICI:
1096-6080(200111)64:1<111:DMOIFB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSPIRATORY AIR-FLOW; UPPER RESPIRATORY-TRACT; PROTEIN CROSS-LINKS; COVALENT BINDING; RHESUS-MONKEYS; F344 RAT; EPIDEMIOLOGIC EVIDENCE; COMPUTER-SIMULATION; CELL-PROLIFERATION; FISCHER-344 RATS;
Keywords:
formaldehyde; nasal passages; nasal airflow; nasal uptake; F344 rat; rhesus monkey; human; regional dosimetry; local dosimetry; computational fluid dynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kimbell, JS CIIT Ctr Hlth Res, POB 12137,6 Davis Dr, Res Triangle Pk, NC 27709 USA CIIT Ctr Hlth Res POB 12137,6 Davis Dr Res Triangle Pk NC USA 27709
Citazione:
J.S. Kimbell et al., "Dosimetry modeling of inhaled formaldehyde: Binning nasal flux predictionsfor quantitative risk assessment", TOXICOL SCI, 64(1), 2001, pp. 111-121

Abstract

Interspecies extrapolations of tissue dose and tumor response have been a significant source of uncertainty in formaldehyde cancer risk assessment. The ability to account for species-specific variation of dose within the nasal passages would reduce this uncertainty. Three-dimensional, anatomically realistic, computational fluid dynamics (CFD) models of nasal airflow and formaldehyde gas transport in the F344 rat, rhesus monkey, and human were used to predict local patterns of wall mass flux (pmol/[mm(2)- h-ppm]). The nasal surface of each species was partitioned by flux into smaller regions (flux bins), each characterized by surface area and an average flux value. Rat and monkey flux bins were predicted for steady-state inspiratory airflowrates corresponding to the estimated minute volume for each species. Humanflux bins were predicted for steady-state inspiratory airflow at 7.4, 15, 18, 25.8, 31.8, and 37 l/min and were extrapolated to 46 and 50 l/min. Fluxvalues higher than half the maximum flux value (flux median) were predicted for nearly 20% of human nasal surfaces at 15 l/min, whereas only 5% of rat and less than 1% of monkey nasal surfaces were associated with fluxes higher than flux medians at 0.576 l/min and 4.8 l/min, respectively. Human nasal flux patterns shifted distally and uptake percentage decreased as inspiratory flow rate increased. Flux binning captures anatomical effects on fluxand is thereby a basis for describing the effects of anatomy and airflow on local tissue disposition and distributions of tissue response. Formaldehyde risk models that incorporate flux binning derived from anatomically realistic CFD models will have significantly reduced uncertainty compared with risk estimates based on default methods.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:54:29