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Titolo:
Dosimetry modeling of inhaled formaldehyde: Comparisons of local flux predictions in the rat, monkey, and human nasal passages
Autore:
Kimbell, JS; Subramaniam, RP; Gross, EA; Schlosser, PM; Morgan, KT;
Indirizzi:
CIIT Ctr Hlth Res, Res Triangle Pk, NC 27709 USA CIIT Ctr Hlth Res Res Triangle Pk NC USA 27709 Triangle Pk, NC 27709 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 1, volume: 64, anno: 2001,
pagine: 100 - 110
SICI:
1096-6080(200111)64:1<100:DMOIFC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSPIRATORY AIR-FLOW; UPPER RESPIRATORY-TRACT; PROTEIN CROSS-LINKS; F344 RATS; CELL-PROLIFERATION; RHESUS-MONKEYS; COMPUTER-SIMULATION; INHALATION EXPOSURE; COVALENT BINDING; GAS UPTAKE;
Keywords:
formaldehyde; nasal uptake; computational fluid dynamics; F344 rat; rhesus monkey; human; nasal passages;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kimbell, JS CIIT Ctr Hlth Res, POB 12137,6 Davis Dr, Res Triangle Pk, NC 27709 USA CIIT Ctr Hlth Res POB 12137,6 Davis Dr Res Triangle Pk NC USA 27709
Citazione:
J.S. Kimbell et al., "Dosimetry modeling of inhaled formaldehyde: Comparisons of local flux predictions in the rat, monkey, and human nasal passages", TOXICOL SCI, 64(1), 2001, pp. 100-110

Abstract

Formaldehyde-induced nasal squamous cell carcinomas in rats and squamous metaplasia in rats and rhesus monkeys occur in specific regions of the nose with species-specific distribution patterns. Experimental approaches addressing local differences in formaldehyde uptake patterns and dose are limitedby the resolution of dissection techniques used to obtain tissue samples and the rapid metabolism of absorbed formaldehyde in the nasal mucosa. Anatomically accurate, 3-dimensional computational fluid dynamics models of F344rat, rhesus monkey, and human nasal passages were used to estimate and compare regional inhaled formaldehyde uptake patterns predicted among these species. Maximum flux values, averaged over a breath, in nonsquamous epithelium were estimated to be 2620, 4492, and 2082 pmol/(mm(2)-ppm) in the rat, monkey, and human respectively. Flux values predicted in sites where cell proliferation rates were measured as similar in rats and monkeys were also similar, as were fluxes predicted in a region of high tumor incidence in the rat nose and the anterior portion of the human nose. Regional formaldehyde flux estimates are directly applicable to clonal growth modeling of formaldehyde carcinogenesis to help reduce uncertainty in human cancer risk estimates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:50:50