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Titolo:
The acute effect of calcium carbonate on the intestinal absorption of levothyroxine
Autore:
Singh, N; Weisler, SL; Hershman, JM;
Indirizzi:
Vet Affairs Greater Los Angeles Healthcare Syst, Dept Endocrinol & Metab, Los Angeles, CA 90073 USA Vet Affairs Greater Los Angeles Healthcare Syst Los Angeles CA USA 90073
Titolo Testata:
THYROID
fascicolo: 10, volume: 11, anno: 2001,
pagine: 967 - 971
SICI:
1050-7256(200110)11:10<967:TAEOCC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALUMINUM HYDROXIDE; THYROXINE; HYPOTHYROIDISM; THERAPY; SUCRALFATE; EFFICACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Singh, N Vet Affairs Greater Los Angeles Healthcare Syst, Dept Internal Med, 111G,11301 Wilshire Blvd, Los Angeles, CA 90073 USA Vet Affairs Greater Los Angeles Healthcare Syst 111G,11301 Wilshire Blvd Los Angeles CA USA 90073
Citazione:
N. Singh et al., "The acute effect of calcium carbonate on the intestinal absorption of levothyroxine", THYROID, 11(10), 2001, pp. 967-971

Abstract

To determine the acute effect of calcium, we measured levothyroxine absorption after ingestion of thyroxine (T4) with and without simultaneous ingestion of calcium (as calcium carbonate) in seven volunteers without thyroid disease. Serum total T-4, total triiodothyronine (T-3), free T-4, and thyrotropin (TSH) levels were measured after ingestion of 1,000 mug of levothyroxine on two separate visits at 4-week intervals: (1) levothyroxine alone and(2) levothyroxine together with 2.0 g of calcium as calcium carbonate. Theamount of absorbed levothyroxine was calculated as the incremental rise inserum T-4 level during the first 6 hours multiplied by the volume of distribution for the hormone. When 1,000 mug of levothyroxine alone was given tosubjects, the maximum average total T-4 absorption was 837 mug (83.7% of the dose ingested) at 120 minutes. When levothyroxine was coadministered with 2.0 g of calcium (as calcium carbonate), the maximum average T-4 absorption decreased to 579 mug (57.9% of the dose ingested) at 240 minutes. The total levothyroxine absorption over 6 hours was Significantly greater with thyroxine than that with thyroxine and calcium (p = 0.02). The administrationof calcium and levothyroxine in these subjects was associated with a significant reduction in the peak increment in serum total T-4 (P = 0.02) and free T-4 levels (p = 0.03), as well as a significant reduction in the overallincrement in serum total T-4 (p = 0.003), free T-4 (p = 0.002), and total T-3 levels (p = 0.01) over four time points (120 minutes, 240 minutes, 360 minutes, 1,440 minutes). In summary, this pharmacokinetic study in seven volunteers indicates that calcium carbonate acutely reduces T-4 absorption.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:54:31