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Titolo:
Altered dendritic spine density in animal models of depression and in response to antidepressant treatment
Autore:
Norrholm, SD; Ouimet, CC;
Indirizzi:
Florida State Univ, Biomed Res Facil 211, Program Neurosci, Dept Psychol, Tallahassee, FL 32306 USA Florida State Univ Tallahassee FL USA 32306 ol, Tallahassee, FL 32306 USA
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 42, anno: 2001,
pagine: 151 - 163
SICI:
0887-4476(200112)42:3<151:ADSDIA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOSTEROID RECEPTOR-BINDING; ASTROGLIAL 5-HT1A RECEPTORS; HIPPOCAMPAL CELL-CULTURES; DENTATE GRANULE CELLS; OLFACTORY BULBECTOMY; ADULT-RATS; MATERNAL-DEPRIVATION; QUANTITATIVE CHANGES; SEROTONIN DEPLETION; LOCUS COERULEUS;
Keywords:
synaptic plasticity; dendritic morphology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Ouimet, CC Florida State Univ, Biomed Res Facil 211, Program Neurosci, Dept Psychol, Tallahassee, FL 32306 USA Florida State Univ Tallahassee FL USA32306 ssee, FL 32306 USA
Citazione:
S.D. Norrholm e C.C. Ouimet, "Altered dendritic spine density in animal models of depression and in response to antidepressant treatment", SYNAPSE, 42(3), 2001, pp. 151-163

Abstract

Olfactory bulbectomy, neonatal clomipramine administration, and maternal deprivation have been employed as animal models of depression. Each model isunique with respect to the experimental manipulations required to produce "depressive" signs, expression and duration of these signs, and response toantidepressant treatments. Dendritic spines represent a possible anatomical substrate for the enduring changes seen with depression and we have previously shown that chronic antidepressant drug exposure alters the density ofhippocampal dendritic spines in an enduring fashion. The purpose of the present study was to determine whether persistent alteration of hippocampal spine density is a common element in each of these different models of depression and whether such alterations could be reversed with chronic antidepressant treatment. The results show that olfactory bulbectomy reduced spine density in CA1, CA3, and dentate gyrus compared to sham-operated controls. Chronic treatment with amitriptyline, a tricyclic antidepressant, reversed the bulbectomy-induced reduction in dendritic spine density in CA1, CA3, anddentate gyrus, whereas treatment with mianserin, an atypical antidepressant, reversed this reduction only in dentate gyrus. On the other hand, neither neonatal clomipramine administration nor maternal deprivation affected hippocampal dendritic spine density. Repeated neonatal handling, however, as a control or as part of the maternal deprivation procedure, elevated spine density in dentate gyrus. These data suggest that long-lasting alterations in hippocampal dendritic spine density contribute to the neural mechanism underlying the olfactory bulbectomy model of depression, but not the neonatal clomipramine or maternal deprivation models. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:39:27