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Titolo:
Treatment of mitochondrial cytopathies
Autore:
Gold, DR; Cohen, BH;
Indirizzi:
Cleveland Clin Fdn, Sect Pediat Neurol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Neurol, Cleveland, OH 44195 USA
Titolo Testata:
SEMINARS IN NEUROLOGY
fascicolo: 3, volume: 21, anno: 2001,
pagine: 309 - 325
SICI:
0271-8235(2001)21:3<309:TOMC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; KEARNS-SAYRE SYNDROME; COMPLEX-I DEFICIENCY; HEREDITARY OPTIC NEUROPATHY; LACTIC-ACIDOSIS; COENZYME-Q; SODIUM DICHLOROACETATE; SKELETAL-MUSCLE; OXIDATIVE-PHOSPHORYLATION; CREATINE SUPPLEMENTATION;
Keywords:
mitochondrial encephalomyopathy; coenzyme Q(10); carnitine; experimental treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Cohen, BH Cleveland Clin Fdn, Sect Pediat Neurol, 9500 Euclid Ave,Desk S-80, Cleveland, OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave,Desk S-80 Cleveland OH USA 44195
Citazione:
D.R. Gold e B.H. Cohen, "Treatment of mitochondrial cytopathies", SEM NEUROL, 21(3), 2001, pp. 309-325

Abstract

Mitochondrial cytopathies are clinically and biochemically heterogeneous disorders affecting energy production. Because of the diverse symptoms spanning organ systems, the large number of biochemical and genetic defects, andan unpredictable clinical course, there are limited data regarding proven effective therapies. In general, treatments for mitochondrial cytopathies are intended to augment energy production as well as reduce the production of free radicals and other toxic metabolites that further limit the generation of cellular energy. Theoretically, treatment can be aimed at increasing respiratory chain activity by supplementing relative deficiencies of cofactors required for proper functioning. Possible strategies to consider may include dietary management, supplemental vitamins and cofactors, and/or specific medications aimed at a particular symptom.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:08:06