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Titolo:
Analysis of the immune status in Latvian Chernobyl clean-up workers with nononcological thyroid diseases
Autore:
Kurjane, N; Bruvere, R; Shitova, O; Romanova, T; Jaunalksne, I; Kirschfink, M; Sochnevs, A;
Indirizzi:
Latvian State Univ, Biomed Res & Study Ctr, LV-1002 Riga, Latvia Latvian State Univ Riga Latvia LV-1002 & Study Ctr, LV-1002 Riga, Latvia Rigas Stradina Univ, Inst Immunol, LV-1002 Riga, Latvia Rigas Stradina Univ Riga Latvia LV-1002 st Immunol, LV-1002 Riga, Latvia P Stradins Univ Hosp, LV-1002 Riga, Latvia P Stradins Univ Hosp Riga Latvia LV-1002 Univ Hosp, LV-1002 Riga, Latvia Univ Heidelberg, Inst Immunol, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany
Titolo Testata:
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
fascicolo: 5, volume: 54, anno: 2001,
pagine: 528 - 533
SICI:
0300-9475(200111)54:5<528:AOTISI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEAD-EXPOSED WORKERS; KILLER CELL-ACTIVITY; IMMUNOLOGICAL FEATURES; MULTINODULAR GOITER; IMMUNOGLOBULIN-G; T-CELL; ACCIDENT; COMPLEMENT; RADIATION; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kurjane, N Rigas Stradina Univ, Inst Immunol, Dzirciema 16, LV-1007 Riga, Latvia Rigas Stradina Univ Dzirciema 16 Riga Latvia LV-1007 a, Latvia
Citazione:
N. Kurjane et al., "Analysis of the immune status in Latvian Chernobyl clean-up workers with nononcological thyroid diseases", SC J IMMUN, 54(5), 2001, pp. 528-533

Abstract

The aim of the present work was to characterize the immune status of 385 individuals who participated in the 1986-90 clean-up work of the after effects of the Chernobyl nuclear power plant explosion. Fifty-nine Chernobyl clean-up workers developed the most common thyroid diseases; euthyroid nodularand diffuse goiter; 47 healthy blood donors were taken as controls. The levels of immunoglobulins (IgA, IgG and IgM), the numbers of peripheral bloodleukocytes, lymphocytes, monocytes, T lymphocytes and their subpopulations(CD3+, CD4+, CD8+), B lymphocytes (CD19+), natural killer (NK) cells (CD16), classical and alternative pathway activity of complement (CH50, APH50),the C3 split product C3d, and neutrophil phagocytosis were determined in the peripheral blood. We found a significantly decreased number of CD16+ cells (natural killer), of CD4+ and CD8+ T lymphocytes, a reduced neutrophil phagocytic activity as well as a significant complement activation in Chernobyl clean-up workers with and without thyroid diseases when compared with normal levels and those in the control group. In addition, the number of CD3 and CD4+ cells was significantly higher in patients with nodular goiter when compared with that in patients with diffuse goiter. Levels of IgG and numbers of monocytes were significantly decreased in persons who worked in Chernobyl in 1986 during the first 2 months after the accident (with maximalradiation exposure) but were without correlation to thyroid disorders. Ourresults clearly reflect an impaired immune system in the Chernobyl clean-up workers even 10-14 years after the nuclear accident.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:43:53