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Titolo:
The role of technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography (SPECT) in the detection of cardiovascular involvement in systemic lupus erythematosus patients with non-specific chest complaints
Autore:
Sun, SS; Shiau, YC; Tsai, SC; Lin, CC; Kao, A; Lee, CC;
Indirizzi:
China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan China Med Coll Hosp Taichung Taiwan 404 t Nucl Med, Taichung 404, Taiwan China Med Coll Hosp, Dept Family Med, Taichung 404, Taiwan China Med Coll Hosp Taichung Taiwan 404 Family Med, Taichung 404, Taiwan China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan China Med Coll Hosp Taichung Taiwan 404 pt Med Res, Taichung 404, Taiwan Far Eastern Mem Hosp, Dept Nucl Med, Taipei, Taiwan Far Eastern Mem Hosp Taipei Taiwan Hosp, Dept Nucl Med, Taipei, Taiwan Natl Taiwan Univ, Coll Elect Engn, Inst Biomed Engn, Taipei 10764, Taiwan Natl Taiwan Univ Taipei Taiwan 10764 t Biomed Engn, Taipei 10764, Taiwan Show Chwan Mem Hosp, Dept Nucl Med, Chunghua, Taiwan Show Chwan Mem Hosp Chunghua Taiwan sp, Dept Nucl Med, Chunghua, Taiwan
Titolo Testata:
RHEUMATOLOGY
fascicolo: 10, volume: 40, anno: 2001,
pagine: 1106 - 1111
SICI:
1462-0324(200110)40:10<1106:TROTSM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE; MANIFESTATIONS; ABNORMALITIES;
Keywords:
Tc-99m-sestamibi SPECT; systemic lupus erythematosus; coronary artery disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Kao, A China Med Coll Hosp, Dept Nucl Med, 2 Yuh Der Rd, Taichung 404, Taiwan China Med Coll Hosp 2 Yuh Der Rd Taichung Taiwan 404 g 404, Taiwan
Citazione:
S.S. Sun et al., "The role of technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography (SPECT) in the detection of cardiovascular involvement in systemic lupus erythematosus patients with non-specific chest complaints", RHEUMATOLOG, 40(10), 2001, pp. 1106-1111

Abstract

Objectives. Systemic lupus erythematosus (SLE) can affect multiple organs. Coronary artery disease has received increasing recognition as a major cause of morbidity and mortality in SLE in recent years. The purpose of this study was to evaluate the utility of technetium-99m sestamibi single-photon emission computed tomography (Tc-99m-sestamibi SPECT) in the detection of cardiovascular involvement in SLE patients with non-specific clinical chest symptoms such as chest discomfort and/or dyspnoea and,or occasional palpitation. Methods. Thirty-three SLE female patients (age range: 22-45 yr) with non-specific complaints such as chest discomfort and/or dyspnoea and/or occasional palpitation were investigated using a Tc-99m-sestamibi myocardial perfusion SPECT scan at rest and after dipyridamole infusion in a stress study. The age- and sex-matched healthy group (24 cases) and SLE patients without any cardiovascular symptoms/signs (28 cases) were also included as controls in this study. The results of the uptake pattern of Tc-99m-sestamibi were classified into four types including normal, persistent perfusion defect, reversible perfusion defect and reverse redistribution. Results. Perfusion abnormalities were detected in 27 cases (seven patientshad persistent perfusion defects, 15 patients had reversible perfusion defects, one patient had both persistent and reversible perfusion defects, twopatients showed a reverse redistribution pattern and two patients had bothreversible perfusion defects and a reverse redistribution pattern). The results of the SPECT in the healthy group were all normal, However, perfusionabnormalities were detected in 12 cases in the group of asymptomatic SLE patients. Conclusions. Tc-99m-sestamibi myocardial perfusion SPECT is a useful non-invasive imaging modality to detect cardiovascular involvement in SLE patients with non-specific clinical complaints of heart disease.

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Documento generato il 20/06/19 alle ore 17:19:40