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Titolo:
Quantitative determination of medroxyprogesterone acetate in plasma by liquid chromatography/electrospray ion trap mass spectrometry
Autore:
Kim, SM; Kim, DH;
Indirizzi:
Korea Adv Inst Sci & Technol, Bioanal & Biotransformat Res Ctr, Seoul 136791, South Korea Korea Adv Inst Sci & Technol Seoul South Korea 136791 36791, South Korea
Titolo Testata:
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
fascicolo: 21, volume: 15, anno: 2001,
pagine: 2041 - 2045
SICI:
0951-4198(2001)15:21<2041:QDOMAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, DH Korea Adv Inst Sci & Technol, Bioanal & Biotransformat Res Ctr, POB 131, Seoul 136791, South Korea Korea Adv Inst Sci & Technol POB 131 Seoul South Korea 136791 rea
Citazione:
S.M. Kim e D.H. Kim, "Quantitative determination of medroxyprogesterone acetate in plasma by liquid chromatography/electrospray ion trap mass spectrometry", RAP C MASS, 15(21), 2001, pp. 2041-2045

Abstract

A sensitive and rapid liquid chromatography/electrospray ion trap mass spectrometry (LC/MS/MS) method has been developed for the quantitative determination of medroxyprogesterone acetate (MPA) in human plasma. Plasma samples(1.0 mL) were simply extracted with pentane and the extracts were analyzedby HPLC with the detection of the analyte in the selective reaction monitoring (SRM) mode. The determination of MPA was accurate and reproducible, with a limit of quantitation of 0.05 ng/mL in plasma. The standard calibration curve for MPA was linear (r = 0.998) over the concentration range 0.05-6.0 ng/mL in human plasma. Analysis precision over the concentration range ofMPA was lower than 18.8% (relative standard deviation, RSD) and accuracy was between 96.2 and 108.7%. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:51:12