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Titolo:
An exploratory study into the effect of group psychotherapy on cardiovascular and immunoreactivity to acute stress in breast cancer patients
Autore:
van der Pompe, G; Antoni, MH; Duivenvoorden, HJ; de Graeff, A; Simonis, RFA; van der Vegt, SGL; Hijnen, CJ;
Indirizzi:
Univ Groningen, Dept Biol Psychiat, NL-9700 RB Groningen, Netherlands UnivGroningen Groningen Netherlands NL-9700 RB B Groningen, Netherlands Erasmus Univ, Fac Med, Helen Dowling Inst Biopsychosocial Med, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Erasmus Univ, Fac Med, Dept Med Psychol & Psychotherapy, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Univ Utrecht Hosp, NL-3584 CX Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands NL-3584 CX CX Utrecht, Netherlands Hosp Oudenrijn, Utrecht, Netherlands Hosp Oudenrijn Utrecht NetherlandsHosp Oudenrijn, Utrecht, Netherlands Univ Hosp Children & Youth, Utrecht, Netherlands Univ Hosp Children & Youth Utrecht Netherlands th, Utrecht, Netherlands Het Wilhelmina Childrens Hosp, Utrecht, Netherlands Het Wilhelmina Childrens Hosp Utrecht Netherlands Utrecht, Netherlands Hosp Groene Hart, Gouda, Netherlands Hosp Groene Hart Gouda NetherlandsHosp Groene Hart, Gouda, Netherlands Univ Miami, Dept Psychiat & Psychol, Miami, FL 33152 USA Univ Miami MiamiFL USA 33152 ept Psychiat & Psychol, Miami, FL 33152 USA
Titolo Testata:
PSYCHOTHERAPY AND PSYCHOSOMATICS
fascicolo: 6, volume: 70, anno: 2001,
pagine: 307 - 318
SICI:
0033-3190(200111/12)70:6<307:AESITE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
KILLER-CELL-ACTIVITY; ADRENERGIC-BLOCKADE; IMMUNE-RESPONSES; MENTAL STRESS; DEPRESSION; ENDOCRINE; HUMANS;
Keywords:
breast cancer; tamoxifen; nonsteroidal antiestrogenic treatment psychotherapy, experiential-existential randomized trial; immune system; natural killer cells; endocrine system; cardiovascular reaction; acute psychological stress; speech task; emotional expression; psychological distress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: van der Pompe, G Univ Groningen, Dept Biol Psychiat, POB 30001, NL-9700 RBGroningen, Netherlands Univ Groningen POB 30001 Groningen Netherlands NL-9700 RB
Citazione:
G. van der Pompe et al., "An exploratory study into the effect of group psychotherapy on cardiovascular and immunoreactivity to acute stress in breast cancer patients", PSYCHOTH PS, 70(6), 2001, pp. 307-318

Abstract

Background. Previous studies of cancer patients investigated the effect ofpsychological treatment on basal endocrine and immune values. Using a randomized experiment, we explored the effect of a 13-week experiential-existential group psychotherapy (EEGP) program on the reactivity to a speech task in breast cancer patients. We explored whether changes in cardiovascular and immune reactivity to a speech task over the 3-month period correlated with changes in psychological distress and emotional expression. Methods: Patients who had been treated for early-stage breast cancer and who were diagnosed as having either positive axillary lymph nodes or distant metastases were randomly assigned to either EEGP or a waiting list control (WLC) condition. We continuously recorded heart rate (HR), diastolic (DBP) and systolic blood pressure (SBP) in response to the speech task before and after treatment. We also measured lymphocyte proliferation to pokeweed PWM) and phytohemagglutinin (PHA), and natural killer cell activity (NKCA) as well as peripheral blood lymphocyte distributions in blood samples that were drawn before, during and after the speech task. Results: Patients in EEGP had smaller increases in natural killer (NK) cells induced by the speech task after treatment versus task-induced values observed at study entry and greater than pre-/post-treatment changes seen in patients randomized to the WLC. A similar pattern emerged with respect to NKCA over the intervention period, whichwas independent of the changes in NK cells. There were no differences between patients assigned to EEGP and WLC in HR, DBP and SBP responses as well as in changes in PWM- and PHA-induced lymphocyte proliferation in response to the speech task measured before and after the 3-month intervention period. Individual differences in pre-/post-treatment increases in emotional expression but not in psychological distress were significantly associated with smaller changes in the number and function of NK cells over the 3-month period. Conclusions: These findings may indicate that emotional expression during EEGP may render breast cancer patients more comfortable expressing their emotional responses to the speech challenge, which, in turn, results insmaller stress-induced changes in NK cells and function. Copyright (C) 2001

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:27:56