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Titolo:
Fluoxetine and fluvoxamine combined with individual cognitive-behaviour therapy in binge eating disorder: A one-year follow-up study
Autore:
Ricca, V; Mannucci, E; Mezzani, B; Moretti, S; Di Bernardo, M; Bertelli, M; Rotella, C; Faravelli, C;
Indirizzi:
Univ Florence, Dept Sci Neurol & Psichiat, I-50134 Florence, Italy Univ Florence Florence Italy I-50134 & Psichiat, I-50134 Florence, Italy Univ Florence, Dept Pathophysiol, Sect Metab Dis & Endocrinol, I-50134 Florence, Italy Univ Florence Florence Italy I-50134 Endocrinol, I-50134 Florence, Italy
Titolo Testata:
PSYCHOTHERAPY AND PSYCHOSOMATICS
fascicolo: 6, volume: 70, anno: 2001,
pagine: 298 - 306
SICI:
0033-3190(200111/12)70:6<298:FAFCWI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; OVERWEIGHT WOMEN; BULIMIA-NERVOSA; WEIGHT-LOSS; OBESE; DESIPRAMINE; COMORBIDITY; DEPRESSION; EFFICACY;
Keywords:
binge eating disorder; cognitive-behaviour therapy; fluoxetine; fluvoxamine; follow-up;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Faravelli, C Univ Florence, Dept Sci Neurol & Psichiat, Viale Morgagni 85,I-50134 Florence, Italy Univ Florence Viale Morgagni 85 Florence Italy I-50134 Italy
Citazione:
V. Ricca et al., "Fluoxetine and fluvoxamine combined with individual cognitive-behaviour therapy in binge eating disorder: A one-year follow-up study", PSYCHOTH PS, 70(6), 2001, pp. 298-306

Abstract

Background: The treatment of binge eating disorder (BED) is still the object of debate. In the present study, the effectiveness of antidepressant drugs (fluoxetine FLX - 60 mg/day, fluvoxamine - FLV -300 mg/day), cognitive-behavioural therapy (CBT) and combined treatments (CBT + FLX, CBT + FLV) hasbeen evaluated in a randomized, clinical trial. Results at the end of the active treatment (in the 24th week) and 1-year follow-up outcomes have beenevaluated. Methods: One hundred eight (44 M, 64 F) BED patients were randomly assigned to either CBT, FLX (60 mg/day), FLV (300 mg/day), CBT + FLX orCBT + FLV, for 24 weeks. At the beginning (TO), at the end (T1) of treatment and after 1 year (T2), body mass index (BMI) and eating attitude and behaviours (by EDE 12.0D) were assessed. Results: At T1, BMI and EDE scores were significantly reduced in CBT, CBT + FLX and CBT + FLV, but not in the FLX and FLV treatment groups. In the CBT + FLV group, a greater (p < 0.05) reduction of EDE total scores was observed, when compared to CBT + FLX or CBTtreatment groups. At T2, BMI was significantly higher than at TI, but still significantly lower than at TO in the CBT, CBT + FLX and CBT + FLV groups, while EDE scores remained unchanged from T1 in all treatment groups. Conclusions: CBT was more effective than FLX or FLV in the treatment of BED. The addition of FLX to CBT does not seem to provide any clear advantage, while the addition of FLV could enhance the effects of CBT on eating behaviours. Modifications of eating behaviours are maintained at the 1-year follow-up, although the lost weight was partly regained. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 06/04/20 alle ore 08:34:08