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Titolo:
Proteomics for studying cancer cells and the development of chemoresistance
Autore:
Hutter, G; Sinha, P;
Indirizzi:
Univ Klinikum Berlin, Charite, Inst Lab Med & Pathobiochem, D-10117 Berlin, Germany Univ Klinikum Berlin Berlin Germany D-10117 hem, D-10117 Berlin, Germany Univ Berlin, Klinikum Benjamin Franklin, Med Klin 3, Berlin, Germany Univ Berlin Berlin Germany njamin Franklin, Med Klin 3, Berlin, Germany
Titolo Testata:
PROTEOMICS
fascicolo: 10, volume: 1, anno: 2001,
pagine: 1233 - 1248
SICI:
1615-9853(200110)1:10<1233:PFSCCA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
2-DIMENSIONAL GEL-ELECTROPHORESIS; CYSTEINE PROTEASE INHIBITORS; NON-DETERGENT SULFOBETAINES; POLYMERASE CHAIN-REACTION; IMMOBILIZED PH GRADIENTS; ACQUIRED DRUG-RESISTANCE; MYC GENE AMPLIFICATION; MULTIDRUG-RESISTANCE; BREAST-CANCER; MASS-SPECTROMETRY;
Keywords:
cancer; drug resistance; multidrug resistance; two-dimensional electrophoresis; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
143
Recensione:
Indirizzi per estratti:
Indirizzo: Sinha, P Univ Klinikum Berlin, Charite, Inst Lab Med & Pathobiochem, Campus ChariteMitte,Schumannstr 20-21, D-10117 Berlin, Germany Univ Klinikum Berlin Campus Charite Mitte,Schumannstr 20-21 Berlin Germany D-10117
Citazione:
G. Hutter e P. Sinha, "Proteomics for studying cancer cells and the development of chemoresistance", PROTEOMICS, 1(10), 2001, pp. 1233-1248

Abstract

Extensive studies during the last decades have identified several mechanisms through which cells escape the cytotoxic effects of a variety of chemotherapeutic drugs. One type of drug resistance is called multidrug resistance(MDR), because selection with one anticancer drug leads to cross-resistance with a wide range of other drugs. These MDR cells express frequently plasma transport proteins like p-glycoprotein. But cellular resistance to chemotherapy is multifactorial and may be affected by the cell cycle stage and proliferation status, biochemical mechanisms such as detoxification, cellular drug transport, or DNA replication and repair mechanisms. Several laboratory techniques, such as polymerase chain reaction, immunocytochemistry, flow cytometry, blotting, and fluorescent microscopy have been used for the identification of MDR markers and mechanisms. We review the possibilities in studying cancer biology and development of chemoresistance in cancer treatment using the proteomic approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:31:04